Chemotherapy
Microbiology
Assessment of Timed Bacteriostatic and Bactericidal Activities of Cephalothin against Gram-Positive and Gram-Negative BacteriaMasuda G. · Negishi M. · Young C.Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital, Japan
|
|
Log in to MyKarger to check if you already have access to this content.
KAB
Buy a Karger Article Bundle (KAB) and profit from a discount!
If you would like to redeem your KAB credit, please log in.
Save over 20% compared to the individual article price.
Article / Publication Details
Published online: September 08, 2009
Issue release date: 1982
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)
For additional information: https://www.karger.com/CHE
Abstract
The comparative bacteriostatic and bactericidal activities of cephalothin were assessed in broth medium with special reference to the period of exposure of microbes to the drug. The bacteriostatic concentration with a brief period of exposure (6 h) was lower than the conventional MIC for Escherichia coli and Klebsiella sp. When the period of exposure was prolonged (18–42 h), the bacteriostatic concentration almost corresponded with the MIC. In contrast to these gram-negatives, the bacteriostatic concentration with a brief period of exposure roughly corresponded with the MIC for strains of Staphylococcus aureus and was higher for enterococcus. When a comparison of the bacteriostatic and the bactericidal concentrations was used as the criterion for assessment, the mode of action of cephalothin appeared to be bactericidal to most of the gram-negatives. This drug was bacteriostatic to a number of strains of gram-positives, in particular to enterococcus, especially when microbes were exposed to the drag over a brief period of time.
© 1982 S. Karger AG, Basel
Related Articles:
Article / Publication Details
Published online: September 08, 2009
Issue release date: 1982
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)
For additional information: https://www.karger.com/CHE
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Get Permission