Chemotherapy

Microbiology

In vitro Activity of Moxalactam against Pathogenic Bacteria and Its Comparison with Other Antibiotics

Perrymann F.b · Flournoy D.J.a,c · Qadri S.M.H.a,b

Author affiliations

aUniversity of Oklahoma Health Sciences Center, bOklahoma Memorial Hospital and Clinics, cVeterans Administration Medical Center, Oklahoma City, Okla., USA

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Chemotherapy 1983;29:37–42

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Article / Publication Details

First-Page Preview
Abstract of Microbiology

Published online: September 08, 2009
Issue release date: 1983

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)

For additional information: https://www.karger.com/CHE

Abstract

843 isolates from clinical specimens were tested against moxalactam by disc agar diffusion. The bacteria used in this study consisted of Escherichia coli, Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter cloacae, Klebsiella pneumoniae, Proteus mirabilis, Providencia rettgeri, Pseudomonas aeruginosa, Serratia marcescens, Staphylococcus aureus, Staphylococcus epidermidis and group B and group D Streptococci. In vitro activity of moxalactam was compared with the following antibiotics: ampicillin, amikacin, carbenicillin, cefamandole, cefoxitin, cephalothin, chloramphenicol, clindamycin, colistin, erythromycin, gentamicin, oxacillin, penicillin, tetracycline, tobramycin, trimethoprim-sulfamethoxazole and vancomycin. Of the 471 strains of Enterobacteriaceae tested, 466 (98.9%) were susceptible to moxalactam. Except for penicillin G, the gram-positive cocci were generally more resistant to moxalactam than the other beta-lactam antibiotics. Moxalactam was comparable to gentamicin, as far as its activity against P. aeruginosa was concerned, but was less effective than amikacin, tobramycin, carbenicillin or colistin.

© 1983 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Microbiology

Published online: September 08, 2009
Issue release date: 1983

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)

For additional information: https://www.karger.com/CHE


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