Chemotherapy
Experimental Chemotherapy
Antiandrogen and Antineoplastic Effects of a Novel Drug, CPC10997Ford L.C. · Kasha W. · Chang N.H.C. · DeLange R.J.Department of Obstetrics and Gynecology, Oncology Division, Department of Biological Chemistry, UCLA Medical Center, Los Angeles, Calif., USA
Keywords: AntiandrogenAntineoplastic drugCPC10997 |
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Article / Publication Details
Published online: September 09, 2009
Issue release date: 1985
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)
For additional information: https://www.karger.com/CHE
Abstract
CPC 10997 was found to be effective in vitro as an antiandrogen without effects on either the estrogen or the progesterone receptors in carcinomas of the breast, ovary and prostate as well as in malignant melanomas. Using the clonogenic assay of Salmon et al. [Cancer Treat. Rep. 65: 1–12, 1981], CPC 10997 was found to be more effective against carcinomas of the breast, the kidney, the ovary and the prostate than conventional antineoplastic agents in the majority of tumors tested. In view of the very favorable toxicology profiles and in vitro efficacy, further trials using CPC 10997 as an antineoplastic agent are indicated.
© 1985 S. Karger AG, Basel
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Article / Publication Details
Published online: September 09, 2009
Issue release date: 1985
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)
For additional information: https://www.karger.com/CHE
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