Chemotherapy
Pharmacology
Biliary Elimination of Cefotiam, an Experimental and Clinical StudyBrogard J.M.a · Arnaud J.P.b · Blickle J.F.a · Levy P.a · Dorner M.a · Lautier F.cDepartments of aInternal Medicine, Medical Clinic B, and bSurgery, CMCO Schiltigheim; cInstitute of Hygiene, University Hospital, Strasbourg, France
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Article / Publication Details
Published online: September 09, 2009
Issue release date: 1986
Number of Print Pages: 14
Number of Figures: 0
Number of Tables: 0
ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)
For additional information: https://www.karger.com/CHE
Abstract
Five isolated rabbit livers were in vitro perfused over a 3-hour period. After addition of 10 mg of cefotiam to the circulating blood, a biliary peak concentration of 76.2 ± 14.2 μg/ml (mean ± SEM) was reached between the 90th and 120th min; 3.1 ± 0.4% of the dose given was excreted in the bile during the 3-hour period. In 10 recently cholecystectomized patients provided with a T-tube drain, 1 g of cefotiam was given intravenously. A biliary peak concentration of 340 ± 81 μg/ml was observed 2 h later. 1.8 ± 0.7% of the administered dose was recovered in the bile during the 12-hour period. In 5 clinically normal subjects given intravenously 1 g of cefotiam, 0.5 ± 0.2% of the administered dose was found in the duodenal fluid aspirated over a 4-hour period. Cefotiam concentrations measured in choledochal and gallbladder bile collected simultaneously during operation 1 h after intravenous administration of 1 g of the drug to 10 patients were 502 ± 102 μg/ml and 143 ± 39 μg/ml, respectively; they exceeded significantly the concentration determined in the serum sampled at the same time (17.9 ± 2.6 μg/ml). The biliary parameters of cefotiam were compared with those of 14 other β-lactam antibiotics previously studied by the same procedure. The results of the present study are consistent with a possible beneficial effect of cefotiam in the treatment of biliary tract infections.
© 1986 S. Karger AG, Basel
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Article / Publication Details
Published online: September 09, 2009
Issue release date: 1986
Number of Print Pages: 14
Number of Figures: 0
Number of Tables: 0
ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)
For additional information: https://www.karger.com/CHE
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