Chemotherapy

Experimental Chemotherapy

Phagocyte Transport as Mechanism for Enhanced Therapeutic Activity of Liposomal Amphotericin B

Mehta R.T. · McQueen T.J. · Keyhani A. · López-Berestein G.

Author affiliations

Immunobiology and Drug Carriers Section, Division of Medicine, University of Texas M.D. Anderson Cancer Center, Houston, Tex., USA

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Chemotherapy 1994;40:256–264

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Article / Publication Details

First-Page Preview
Abstract of Experimental Chemotherapy

Published online: September 11, 2009
Issue release date: 1994

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)

For additional information: https://www.karger.com/CHE

Abstract

Liposomal amphotericin B (L-AmB) is emerging as one of the most attractive new antifungal agents. We have attempted to show that phagocytic cells circulating in blood play an important role in transport and accumulation of L-AmB at inflammatory sites in vivo. Free AmB or L-AmB was injected intravenously to mice, and the amount of AmB in peritoneal exudate cells was quantitated by high-performance liquid chromatography. Higher levels of AmB were detected in a higher number of mice injected with L-AmB. The presence of L-AmB in inflammatory peritoneal cells after intravenous administration of fluorescence-labeled L-AmB also suggested that macrophages play an important role in the transport of intravenously administered L-AmB to inflammatory sites.

© 1994 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Experimental Chemotherapy

Published online: September 11, 2009
Issue release date: 1994

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)

For additional information: https://www.karger.com/CHE


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