Gerontology
Clinical Section
A Cross-Sectional Study of Familial Clustering in HyperhomocysteinemiaMitani S.a · Ozasa K.a, c · Shigeta M.a · Kuriyama N.a · Ozaki E.a · Mizuno T.a · Yokota S.b · Watanabe Y.aaKyoto Prefectural University of Medicine and bNantan Public Health Office, Kyoto, and cRadiation Effects Research Foundation, Hiroshima City, Japan
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Article / Publication Details
Received: September 08, 2008
Accepted: January 15, 2009
Published online: September 17, 2009
Issue release date: January 2010
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 4
ISSN: 0304-324X (Print)
eISSN: 1423-0003 (Online)
For additional information: https://www.karger.com/GER
Abstract
Background: Hyperhomocysteinemia is correlated with diseases and lifestyle habits. However, there is no epidemiological evidence concerning the distribution and prevalence of hyperhomocysteinemia in a local community. Objective: The purpose of this study was to clarify the distribution and prevalence of hyperhomocysteinemia and the existence or nonexistence of familial clustering. Methods: The subjects were participants in the Basic Health Check Service 1999. We administered a questionnaire and obtained blood samples from 865 subjects (306 men, 559 women) who agreed to participate in our study. Results: Hyperhomocysteinemia was present in 52 men (17.0%) and 25 women (4.5%). Ten subjects who had hyperhomosysteinemia ha a family member who also had hyperhomocysteinemia. The odds ratio for hyperhomocysteinemia adjusted for age and sex was 4.77 (p < 0.01, 95% CI = 1.95–11.65). Conclusion: Hyperhomocysteinemia shows familial clustering. Men and elderly persons were more likely to have hyperhomocysteinemia.
© 2009 S. Karger AG, Basel
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Article / Publication Details
Received: September 08, 2008
Accepted: January 15, 2009
Published online: September 17, 2009
Issue release date: January 2010
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 4
ISSN: 0304-324X (Print)
eISSN: 1423-0003 (Online)
For additional information: https://www.karger.com/GER
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