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Biology of Inflammatory Products: Cytokines

Expression of Th1 and Th2 Immunoregulatory Cytokines by Human Eosinophils

Woerly G. · Roger N. · Loiseau S. · Capron M.

Author affiliations

INSERM U167, Institut Pasteur, and University of Lille II, Lille, France

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Int Arch Allergy Immunol 1999;118:95–97

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Article / Publication Details

First-Page Preview
Abstract of Biology of Inflammatory Products: Cytokines

Published online: April 23, 1999
Issue release date: February – April

Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: https://www.karger.com/IAA

Abstract

Besides cytotoxic mediators, human eosinophils can produce proinflammatory and anti–inflammatory cytokines, as well as growth factors and chemokines. The demonstration that eosinophils from patients could produce IL–5, IL–4 and IL–2 suggested their participation in the regulation of immune response. In the present work, we have examined the presence of Th1 (IFN–γ, IL–2) and Th2 (IL–4, IL–5, IL–10 and IL–13) cytokines in eosinophils from patients or donors by intracellular flow cytometry, and by immunocytochemistry. Whereas almost 100% eosinophils expressed intracellular IFN–γ, IL–2 and IL–10, the expression of IL–4, IL–5 and IL–13 is more variable and increased in patients versus donors. The differential release by eosinophils of Th2 versus Th1 cytokines is suggested both by the decrease of the intracellular content after culture, restricted to IL–4, IL–5 and IL–13, associated with an accumulation of IL–4 and IL–5 in the presence of Brefeldin. These results indicate that, through the preferential release of Th2 cytokines, human eosinophils can participate in the polarization of the immune response.


References

  1. Desreumaux P, Capron M: Eosinophils in allergic reactions. Curr Opin Immunol 1996;8: 790–795.
  2. Dubucquoi S, Capron M: L’éosinophile, une cellule à deux visages dans la réponse inflammatoire; dans L’inflammation. London, Libbey, 1998, pp 55–68.
  3. Desreumaux P, Janin A, Colombel JF, Prin L, Plumas J, Emilie D, Torpier G, Capron A, Capron M: Interleukin–5 messenger RNA expression by eosinophils in the intestinal mucosa of patients with coeliac disease. J Exp Med 1992;175:293–296.
  4. Dubucquoi S, Desreumaux P, Janin A, Klein O, Goldman M, Tavernier J, Capron A, Capron M: Interleukin 5 synthesis by eosinophils: Association with granules and immunoglobulin–dependent secretion. J Exp Med 1994;179: 703–708.
  5. Broide DH, Paine MM, Firestein GS: Eosinophils express interleukin–5 and granulocyte macrophage–colony–stimulating factor mRNA at sites of allergic inflammation in asthmatics. J Clin Invest 1992;90:1414–1424.
  6. Tanaka YE, Delaporte E, Dubucquoi S, Soussi Gounni A, Porchet E, Capron A, Capron M: IL–5 messenger RNA and immunoreactive protein expression by activated eosinophils in lesional atopic dermatitis skin. J Invest Dermatol 1994;103:589–592.
  7. Tomassini M, Tsicopoulos A, Tai PC, Gruart V, Tonnel AB, Prin L, Capron A, Capron M: Release of granule proteins by eosinophils from allergic and nonallergic patients with eosinophilia on immunoglobulin–dependent activation. J Allergy Clin Immunol 1991;88:365– 375.
  8. Nonaka M, Nonaka R, Woolley K, Adelroth E, Miura K, Okhawara Y, Glibetic M, Nakano K, O’Byrne P, Dolovich J, Jordana M: Distinct immunohistochemical localization of IL–4 in human inflamed airway tissues. Il–4 is localized to eosinophils in vivo and is released by peripheral blood eosinophils. J Immunol 1995; 155:3234–3244.
    External Resources
  9. Moqbel R, Ying S, Barkans J, Newman TM, Kimmitt P, Wakelin M, Taborda–Barata L, Meng Q, Corrigan CJ, Durham SR, Kay AB: Identification of messenger RNA for IL–4 in human eosinophils with granule localization and release of the translated product. J Immunol 1995;155:4939–4947.
  10. Swain SL, Weinberg AD, English M, Huston G: IL–4 directs the development of Th2–like helper effectors. J Immunol 1990;145:3796– 3806.
  11. Levi–Schaffer F, Barkans J, Newman TM, Ying S, Wakelin M, Hohenstein R, Barak V, Lacy P, Kay AB, Moqbel R: Identification of interleukin–2 in human peripheral blood eosinophils. Immunology 1996;87:155–161.
    External Resources
  12. Lamkhioued B, Soussi Gounni A, Aldebert D, Delaporte E, Prin L, Capron A, Capron, M: Synthesis of type 1 (IFN–γ) and type 2 (IL–4, IL–5, and IL–10) cytokines by human eosinophils. Ann NY Acad Sci 1996;796:203–208.

Article / Publication Details

First-Page Preview
Abstract of Biology of Inflammatory Products: Cytokines

Published online: April 23, 1999
Issue release date: February – April

Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: https://www.karger.com/IAA


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