Biology of Inflammatory Products: Cytokines
Eosinophil Development and Bone Marrow and Tissue Eosinophils in Atopic AsthmaRobinson D.S.a · North J.a · Zeibecoglou K.a · Ying S.a · Meng Q.a · Rankin S.b · Hamid Q.c · Tavernier J.d · Kay A.B.a
aAllergy and Clinical Immunology and bLeukocyte Biology, Imperial College School of Medicine, National Heart and Lung Institute, London, UK; cMeakins Christie Laboratories, McGill University, Montreal, Canada; dDepartment of Medical Protein Chemistry, Flanders Inter–University Institute for Biotechnology, Gent, Belgium
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Background: Eosinophils develop from bone marrow (BM) progenitors, and interleukin–5 (IL–5) and eotaxin may act in expansion and mobilisation of BM eosinophils in asthma. Methods: We have examined phenotypic changes as CD34+ cells develop to the eosinophil lineage in vitro, and have evaluated BM eosinophils from asthmatic and control subjects for expression of the eotaxin receptor, CCR3. Results: Acquisition of receptors for IL–5 and CCR3 was an early event in eosinophil development. There were increased CD34+ cells, and mature and immature CCR3+ eosinophils in BM from asthmatics. Conclusion: These data suggest that IL–5 may act early in eosinophil development, and that eotaxin has the capacity to mobilise a BM eosinophil pool in asthma.
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