Neonatology
Adrenal Catecholamines Content in Fetal and Newborn RatsEffects of Birth by Caesarian Section, Cold Exposure, Hypoxia, Hypoglycemia and 2-Deoxyglucose Laboratoire de Physiologie comparée, Université Paris VI, Paris
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Article / Publication Details
Published online: September 16, 2009
Issue release date: 1975
Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
Abstract
The adrenal epinephrine content of newborn rats delivered by caesarian section on day 21.5 of gestation and maintained at thermal neutrality (37 °C) did not decrease over the 6 h following birth in spite of a transient phase of hypoglycemia. Cold exposure (30 or 24 °C) of the newborn rats immediately after birth did not decrease their adrenal epinephrine content. A decrease in adrenal epinephrine content is observed in21.5-day-old rat fetuses after insulin-induced hypoglycemia for 4 h, after 2-deoxy-D-glucose injection or after anoxia. In 20.5-day-old rat fetuses, insulin-induced hypoglycemia for 4h or 2-deoxy-D-glucose did not decrease the adrenal epinephrine content of the fetus. No variation was observed in norepinephrine content of the adrenal gland in all these situations. It is concluded that spontaneously occurring hypoglycemia or cold exposure are not sufficient stimuli to induce adrenal epinephrine depletion. It is suggested that hypoxia is perhaps the physiological stimulus for epinephrine secretion in newborn rats.
© 1975 S. Karger AG, Basel
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Article / Publication Details
Published online: September 16, 2009
Issue release date: 1975
Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
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