Neonatology
Perinatal Primate Parathyroid Hormone MetabolismFleischman A.R. · Lerman S. · Oakes G.K. · Epstein M.F. · Chez R.A. · Mintz D.H.Pregnancy Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Md., and Department of Medicine, University of Miami School of Medicine, Miami, Fla.
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Article / Publication Details
Published online: September 16, 2009
Issue release date: 1975
Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
Abstract
Near-term fetal and neonatal parathyroid gland function has been studied in the Rhesus monkey. Fetal serum ionized calcium (Ca++) levels are significantly greater than simultaneously obtained maternal levels. Fetal serum parathyroid hormone (PTH) was undetectable both in the basal state and in association with EDTA-induced fetal hypocalcemia. Induced maternal hypocalcemia was associated with increased maternal serum PTH levels and no change in fetal basal serum Ca++ or PTH levels. Only a minimal decrease in simian neonatal serum Ca++ occurred over the first 48 h of life. Normal adult levels of serum PTH were present as early as 6 h of neonatal life. Induced hypocalcemia at 12 h of age resulted in a significant increase in serum PTH levels.
© 1975 S. Karger AG, Basel
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Article / Publication Details
Published online: September 16, 2009
Issue release date: 1975
Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
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