Neonatology
Perinatal Changes in Glycolytic Function in Response to Hypoxia in the Incubated or Perfused Rat HeartHoerter J.A. · Opie L.H.MRC Ischaemic Heart Disease Research Unit, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, and Laboratoire de physiologie comparée et de physiologie cellulaire, Université de Paris XI, Orsay
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Article / Publication Details
Published online: September 17, 2009
Issue release date: 1978
Number of Print Pages: 18
Number of Figures: 0
Number of Tables: 0
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
Abstract
Glycolysis was assessed in the rat heart during the perinatal period: in the fetus of 16.5 days postcoitum (dpc) and 21.5 dpc (term = 22 dpc) and in the newborn of 1 day postpartum (dpp) and 7 dpp. Glucose uptake, lactate production and glucose incorporation into glycogen were much higher in the fetal than in the newborn heart. Measurements were made of tissue contents of high energy phosphate compounds, lactate and hexose phosphates. Unchanged contents of glucose-6-phosphate and fructose-6-phosphate during hypoxia in spite of an increased flux through the enzyme phosphofructokinase (PFK) suggest that PFK has a regulatory role in the glycolysis as early as 16.5 dpc. The isolated fetal heart was more resistant to hypoxia than the newborn heart: glucose uptake and lactate production were much higher and high energy phosphate compounds and glycogen were better maintained in the fetal heart.
© 1978 S. Karger AG, Basel
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Article / Publication Details
Published online: September 17, 2009
Issue release date: 1978
Number of Print Pages: 18
Number of Figures: 0
Number of Tables: 0
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
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