Neonatology
Original Paper
Effects of Low-Dose Prenatal Corticosteroid Administration on the Premature RatFrank L. · Roberts R.J.Division of Pediatric Clinical Pharmacology and The Toxicology Center, Departments of Pediatrics and Pharmacology, University of Iowa, Iowa City, Iowa
Keywords: DexamethasoneLungMaturationToxicityFetus |
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Article / Publication Details
Published online: September 17, 2009
Issue release date: 1979
Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
Abstract
Administration of dexamethasone (0.2 mg/kg/day) to the pregnant rat on days 19 and 20 of gestation has been found to have marked effects on the body and organ weight of fetuses delivered 1 day prematurely on day 21 of gestation. Longer-term dexamethasone treatment earlier in gestation (days 14–18) had even more pronounced effects on body and organ weights in rat fetuses delivered three days prematurely. Dexamethasone treatment for 2 days prior to delivery had no effect on the survival of 1-, 2- and 3-day premature rats. The marked inhibitory effect on organ and body weight observed in the premature rats resulted from prenatal steroid therapy approximating that used in human pregnancies (dexamethasone 0.2 mg/kg/day for 48 h prior to premature delivery).
© 1979 S. Karger AG, Basel
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Article / Publication Details
Published online: September 17, 2009
Issue release date: 1979
Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
Copyright / Drug Dosage / Disclaimer
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