Neonatology
Pattern of Liver Erythropoiesis in Embryos of Polycythemic MiceNotti I. · Bessler H. · Djaldetti M.Department of Medicine ‘B’ and Hematology Clinic, Hasharon Hospital, Petah-Tiqva, Israel; Tel Aviv University Medical School, Tel Aviv, Israel
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Article / Publication Details
Published online: September 17, 2009
Issue release date: 1982
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
Abstract
Polycythemia induced by hypoxia in pregnant mice caused a marked reduction in the total number of erythroid precursors in the 10th, 11th, and 12th day embryonic livers, as compared with controls. In addition, the maturation of the erythroid precursors in the 11th day embryonic livers of polycythemic mice was markedly inhibited in comparison with that of controls, whereas on the following days of gestation the erythropoiesis in embryonic livers of both polycythemic and control mice exhibited a similar pattern. It is suggested that the reduced erythropoiesis in the 11th day embryonic liver of polycythemic mothers provides a stimulation for embryonic erythropoietin production. Subsequently, it triggers the maturation of progenitor erythroid cells in the livers and induces an increased erythropoietic activity in the plasma of 12th and 13th day pregnant polycythemic mice as was observed in our previous study.
© 1982 S. Karger AG, Basel
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Article / Publication Details
Published online: September 17, 2009
Issue release date: 1982
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
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