Neonatology
Original Paper
Relationship between Resting Glucose Consumption and Insulin Secretion in the Ovine FetusPhilipps A.F. · Porte P.W. · Raye J.R.Department of Pediatrics, University of Connecticut Health Center, Farmington, Conn., USA
Keywords: Fetal SheepInsulinGlucose uptake |
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Article / Publication Details
Published online: September 24, 2009
Issue release date: 1985
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
Abstract
In the chronically catheterized fetal sheep, umbilical glucose uptake has previously been found to be related to maternal glucose concentration over a wide range of values. The relative contribution of fetal insulin secretion to resting umbilical glucose uptake has not previously been assessed. Simultaneous measurements of umbilical glucose uptake and an estimate of fetal insulin secretory rate were performed in 21 fetal lambs in late gestation over 1-hour sampling periods. Because of the relatively narrow range of maternal blood glucose concentrations, no relationship was apparent between maternal glucose concentration and umbilical glucose uptake. However, a significant relationship was present between the area beneath the insulin concentration curve, a rough estimate of insulin secretory rate, and umbilical glucose uptake. The data suggest that fetal insulin secretory rate may be an important regulator of fetal glucose uptake under physiologic circumstances.
© 1985 S. Karger AG, Basel
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Article / Publication Details
Published online: September 24, 2009
Issue release date: 1985
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
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