Neonatology

Original Paper

Quantitative Studies on the Fetal Lipid Metabolism in Rats: Liver Fatty Acid Esterification and Conversion into Carbon Dioxide, and Hepatic Output of Triglycerides and Phospholipids into Serum

Zimmermann T. · Hummel L. · Wagner H.

Author affiliations

Institute of Pathological Biochemistry, Central Laboratory, and Institute of Pathological Physiology, Friedrich Schiller University, Jena, GDR

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Biol Neonate 1986;49:43–50

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: September 24, 2009
Issue release date: 1986

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO

Abstract

Fetal lipid metabolism was studied quantitatively using the 14C-1-palmitate in vivo tracer technique and compartment analysis, and in vitro incorporation experiments. The following conclusions can be drawn from our experiments. (1) Fetal serum free fatty acids (FFA) exchange so rapidly with the FFA of another compartment that the FFA of both compartments can be considered as one homogenous FFA compartment. The turnover time of this compartment was calculated to be 0.76 μmol FFA/min/1 through this compartment. (2) The incorporation of fetal serum FFAs into fetal liver triglyceride fatty acids (TG-FA) and phospholipid fatty acids (PL-FA) was calculated to be 0.05 and 0.14 μmol FFA/min/1, respectively. Thus, only 16 % of the fetal serum FFA is incorporated into fetal liver lipids. (3) The fetal serum TG-FA most likely originate in the fetal liver. (4). The fetal liver puts out 0.025 μmol TG-FA/min/1 and 0.10 μmol PL-FA/min/1 into the fetal serum. The turnover times of fetal serum TG-FA and PL-FA are 100 and 39 min, respectively. (5) The fetal liver conversion rate of fatty acids (FA) into CO2 determined in vitro (0.06 μmol FA/min/1) amounts to about 25% of the rate seen in the whole rat fetus.

© 1986 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: September 24, 2009
Issue release date: 1986

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO


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