Neonatology
Original Paper
Metabolism of Mono-(2-Ethylhexyl)phthalate in Fetal, Neonatal and Adult Rat LiverSjöberg P.a · Bondesson U.b · Gustafsson J.caDepartment of Drugs, National Board of Health and Welfare, bHospital Pharmacy and Psychiatric Research Center, Ulleråker Hospital, and cDepartments of Pediatrics and Pharmaceutical Biochemistry, University of Uppsala, Sweden
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Article / Publication Details
Published online: September 24, 2009
Issue release date: 1988
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
Abstract
The aim of the investigation was to study to what extent maturity influences the metabolism of mono-(2-ethylhexyl)phthalate (MEHP), the primary metabolite of the plasticizer di-(2-ethylhexyl)phthalate. The conversion of MEHP to its (ω-1 )-hydroxylated product was determined in liver microsomes from fetal, neonatal (1- and 5-day-old) and adult rats. Product formation was determined by gas chromatography-mass spectrometry. The results show that fetal and neonatal as well as adult rat livers are capable of metabolizing MEHP by (ω-1)-hydroxylation. Preparations from 1- and 5-day-old rats were much more efficient than those from fetal rats. The transition into adult life gave no further increase in hydroxylase activity as compared to that in 5-day-old rats. The work shows that there is a rapid postnatal development of MEHP (ω-1)-hydroxylase activity in the rat.
© 1988 S. Karger AG, Basel
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Article / Publication Details
Published online: September 24, 2009
Issue release date: 1988
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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