Lung Glycogen Metabolism in Suckling Rats: A Comparative StudyMaritz G.S.
Department of Physiological Sciences, University of the Western Cape, Bellville, South Africa
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Glycogen metabolism was studied in lungs of suckling rats and the data was compared with that of the adult. From the data it appeared that the control of glycogen metabolism of lung tissue of suckling rats differs from that of adult lung. After a 24-hour fasting period, the lung glycogen content of 1- to 2-week-old rats was decreased (p < 0.05). This was accompanied by an increased (10%) phosphorylase activity (p < 0.001). In contrast to this, the lung glycogen content of adult lung increased by about 26% (p < 0.05) while at the same time the hexokinase activity increased by about 39% and the phosphorylase activity decreased by about 65%. Also, the 1- to 2-week-old lung utilized glycogen more readily (9.00 ± 0.04 μmol/g/h) than adult lung (3.70 ± 0.15 μmol/g/h). This means that lung tissue of suckling rats is more dependent on glycogen than adult lung which is probably the reason for the difference in control.
© 1988 S. Karger AG, Basel
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