Neonatology
Original Paper
A Study into the Nature and Organ Source of Digoxin-Like Immunoreactive Substance(s) in the Perinatal PeriodSeccombe D.W.a,b · Pudek M.R.b · Humphries K.H.a · Matthewson B.c · Taylor G.P.d · Jacobson B.E.e · Whitfield M.P.faLipid Research Group, Department of Pathology, Shaughnessy Hospital, and University of British Columbia; bDivision of Clinical Chemistry, Department of Pathology, Vancouver General Hospital, and University of British Columbia; cDivision of Hematology, Department of Pathology, Vancouver General Hospital, and University of British Columbia; dDepartment of Pathology, Children’s Hospital, and University of British Columbia; eDivision of Clinical Chemistry, Department of Pathology, Children’s Hospital, and University of British Columbia, and fDepartment of Pediatrics, Children’s Hospital and University of British Columbia, Vancouver, Canada
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Article / Publication Details
Published online: September 25, 2009
Issue release date: 1989
Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
Abstract
Digoxin-like immunoreactive substance(s) (DLIS) was isolated from sera and autopsy-derived tissue obtained from premature and full-term neonates. The highest tissue level of DLIS was in the small bowel followed by the adrenal, gallbladder and liver. Of the fluids examined, meconium had the highest level of DLIS. Preparative high performance liquid chromatography fractionation of cord blood generated at least six different fractions which not only contained DLIS material but also inhibited canine kidney Na+/K+-ATPase activity. Recovery/inhibition studies indicated that 72% of the canine kidney Na+/K+-ATPase inhibition within one fraction could be accounted for on the basis of progesterone content of the fraction.
© 1989 S. Karger AG, Basel
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Article / Publication Details
Published online: September 25, 2009
Issue release date: 1989
Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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