Neonatology

Original Paper

A Study into the Nature and Organ Source of Digoxin-Like Immunoreactive Substance(s) in the Perinatal Period

Seccombe D.W.a,b · Pudek M.R.b · Humphries K.H.a · Matthewson B.c · Taylor G.P.d · Jacobson B.E.e · Whitfield M.P.f

Author affiliations

aLipid Research Group, Department of Pathology, Shaughnessy Hospital, and University of British Columbia; bDivision of Clinical Chemistry, Department of Pathology, Vancouver General Hospital, and University of British Columbia; cDivision of Hematology, Department of Pathology, Vancouver General Hospital, and University of British Columbia; dDepartment of Pathology, Children’s Hospital, and University of British Columbia; eDivision of Clinical Chemistry, Department of Pathology, Children’s Hospital, and University of British Columbia, and fDepartment of Pediatrics, Children’s Hospital and University of British Columbia, Vancouver, Canada

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Biol Neonate 1989;56:136–146

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: September 25, 2009
Issue release date: 1989

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO

Abstract

Digoxin-like immunoreactive substance(s) (DLIS) was isolated from sera and autopsy-derived tissue obtained from premature and full-term neonates. The highest tissue level of DLIS was in the small bowel followed by the adrenal, gallbladder and liver. Of the fluids examined, meconium had the highest level of DLIS. Preparative high performance liquid chromatography fractionation of cord blood generated at least six different fractions which not only contained DLIS material but also inhibited canine kidney Na+/K+-ATPase activity. Recovery/inhibition studies indicated that 72% of the canine kidney Na+/K+-ATPase inhibition within one fraction could be accounted for on the basis of progesterone content of the fraction.

© 1989 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: September 25, 2009
Issue release date: 1989

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO


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