Neonatology
Original Paper
The Uptake of Amino Acids and Oxygen across the Rabbit Uterus in Normal and Postterm PregnanciesLi H.-Q. · Gilbert M. · Teng C. · Jones R.O. · Murray R.D. · Battaglia F.C.Division of Perinatal Medicine, Department of Pediatrics, University of Colorado, School of Medicine, Denver, Colo., USA
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Article / Publication Details
Published online: September 25, 2009
Issue release date: 1990
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
Abstract
Nineteen pregnant rabbits were studied at three different gestational ages in terms of uterine uptake of amino acids and oxygen under unstressed, steady-state conditions. The three gestational age groups were: (1) 23–25 days, (2) 26–31 days, and (3) 32–34 days (post term). The arteriovenous differences for all amino acids except glutamate and aspartate were significant in groups 1 and 2. Uterine amino acid coefficients of extraction were markedly reduced in the postterm animals (3), despite an increased uterine coefficient of extraction for oxygen. The uterine coefficients of extraction of amino acids were 2–2.5 times greater than those across the pregnant Uterus of the sheep. There was also an increased uptake of amino acid per millimoles/liter of oxygen in the rabbit compared to the sheep. Maternal arterial amino acid concentrations were not significantly different in groups 1 and 2, but the gluconeogenic amino acids serine and alanine were significantly increased in maternal arterial blood of postterm animals.
© 1990 S. Karger AG, Basel
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Article / Publication Details
Published online: September 25, 2009
Issue release date: 1990
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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