Neonatology
Original Paper
Insulin-Like Growth Factor I and II Gene Expression in Balb/C Mouse Liver during Postnatal DevelopmentSingh J.S.a · Rall L.B.b · Styne D.M.aaDepartment of Pediatrics, University of California, Davis, School of Medicine, Davis, Calif.; bChiron Corporation, Emeryville, Calif., USA
Keywords: Growth factorsNeonateWeaningPuberty |
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Article / Publication Details
Published online: September 25, 2009
Issue release date: 1991
Number of Print Pages: 12
Number of Figures: 0
Number of Tables: 0
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
Abstract
We studied the developmental shift from IGF-II to IGF-I mRNA synthesis in Balb/C mouse liver. IGF-I mRNA levels were low at birth, increased with age to peak at weaning, and IGF-I gene expression again increased during puberty. IGF-II expression was high during early postnatal development, but became nondetectable at weaning. Thus in early life there is a reciprocal relationship of rising IGF-I and falling IGF-II mRNA. Northern analysis revealed four IGF-I mRNA transcripts ranging from 1.1–7.0 kb, with the 1.1 kb being the most prominent. Five IGF-II transcripts ranging from 1.7–4.0 kb were found, with the 4,0 kb being the most prominent. The pattern of Serum IGF-I and IGF-II values paralleled liver IGF-I and IGF-II mRNA levels.
© 1991 S. Karger AG, Basel
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Article / Publication Details
Published online: September 25, 2009
Issue release date: 1991
Number of Print Pages: 12
Number of Figures: 0
Number of Tables: 0
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
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