Neonatology

Original Paper

Insulin-Like Growth Factor I and II Gene Expression in Balb/C Mouse Liver during Postnatal Development

Singh J.S.a · Rall L.B.b · Styne D.M.a

Author affiliations

aDepartment of Pediatrics, University of California, Davis, School of Medicine, Davis, Calif.; bChiron Corporation, Emeryville, Calif., USA

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Biol Neonate 1991;60:7–18

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: September 25, 2009
Issue release date: 1991

Number of Print Pages: 12
Number of Figures: 0
Number of Tables: 0

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO

Abstract

We studied the developmental shift from IGF-II to IGF-I mRNA synthesis in Balb/C mouse liver. IGF-I mRNA levels were low at birth, increased with age to peak at weaning, and IGF-I gene expression again increased during puberty. IGF-II expression was high during early postnatal development, but became nondetectable at weaning. Thus in early life there is a reciprocal relationship of rising IGF-I and falling IGF-II mRNA. Northern analysis revealed four IGF-I mRNA transcripts ranging from 1.1–7.0 kb, with the 1.1 kb being the most prominent. Five IGF-II transcripts ranging from 1.7–4.0 kb were found, with the 4,0 kb being the most prominent. The pattern of Serum IGF-I and IGF-II values paralleled liver IGF-I and IGF-II mRNA levels.

© 1991 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: September 25, 2009
Issue release date: 1991

Number of Print Pages: 12
Number of Figures: 0
Number of Tables: 0

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO


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