Neonatology
Original Paper
Splanchnic Blood Flow, Oxygen Delivery and Oxygen Consumption in Hypotensive Newborn PigletsCronin C.M.a,c · Milley J.R.a,baDepartment of Pediatrics, University of Pittsburgh, Pa.; bDepartment of Pediatrics, University of Utah, Salt Lake City, Utah, USA; cDepartment of Paediatrics, University of Manitoba, Winnipeg, Man., Canada
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Article / Publication Details
Published online: September 30, 2009
Issue release date: 1992
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
Abstract
To investigate the relationship between splanchnic visceral oxygen supply and consumption, we altered O2 delivery by decreasing gastrointestinal blood flow during hypotension, and examined the effect on splanchnic oxygen consumption and extraction. We used 10 anesthetized newborn piglets, and measured blood flow using radioactive microspheres. Blood flow fell as perfusion pressure fell in all splanchnic organs, the correlation being most marked in the small intestine. Oxygen consumption was linearly related to blood pressure, and despite a rise in splanchnic oxygen extraction with low blood pressure, splanchnic oxygen consumption was highly dependent on oxygen delivery when oxygen delivery was below a critical value of 0.17 ± 0.05 mmol/100 g/min. We conclude that the newborn piglet gut is incapable of maintaining a constant oxygen supply during the low-flow state produced by hypotension.
© 1992 S. Karger AG, Basel
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Article / Publication Details
Published online: September 30, 2009
Issue release date: 1992
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
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