Neonatology
Original Paper
Intestinal Development and Fatty Acid Binding Protein Activity of Newborn Pigs Fed Colostrum or MilkReinhart G.A.a · Simmen F.A.a · Mahan D.C.a · White M.E.a · Roehrig K.L.baDepartment of Animal Science and Laboratories of Molecular and Developmental Biology, The Ohio State University and The Ohio Agricultural Research and Development Center, Columbus, Ohio; bDepartment of Food Science and Technology, The Ohio State University, Columbus, Ohio, USA
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Article / Publication Details
Published online: September 30, 2009
Issue release date: 1992
Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
Abstract
Newborn pigs (n = 20) were gavage-fed sow’s colostrum, defatted colostrum, milk, defatted milk or a 5% lactose solution over 24 h in order to evaluate effects on growth and functional differentiation of small intestine. Colostrum-fed pigs had greater (p < 0.01) mucosal mass in the proximal half of the small intestine than did the milk- or lactose-fed groups. Total fatty acid binding protein (FABP) activity and FABP activity per mg DNA in proximal intestines of colostrum-fed pigs exceeded that for the lactose group. FABP activities (per g mucosa or mg soluble protein) were greater (p < 0.01) in the proximal segments of small intestines of pigs fed whole versus the corresponding defatted secretion. These results indicate that the feeding of colostrum specifically augments perinatal intestinal growth and differentiation as manifested by increased cellular hypertrophy and FABP activity. Milk lipid and unidentified factor(s) enriched in colostrum are inducers of intestinal FABP activity.
© 1992 S. Karger AG, Basel
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Article / Publication Details
Published online: September 30, 2009
Issue release date: 1992
Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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