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Control of Breathing during Development

A Perspective on Neuropathologic Findings in Victims of the Sudden Infant Death Syndrome: The Triple-Risk Model

Filiano J.J.a · Kinney H.C.a,b

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Departments of aNeurology and bPathology, Children’s Hospital and Harvard Medical School, Boston, Mass., USA

Related Articles for ""

Biol Neonate 1994;65:194–197

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Article / Publication Details

First-Page Preview
Abstract of Control of Breathing during Development

Published online: September 30, 2009
Issue release date: 1994

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO

Abstract

Neuropathologic studies in SIDS victims support the concept that they are not entirely ‘normal’ prior to death, but rather possess underlying vulnerabilities which put them at risk for sudden death. This concept forms a key link in a triple-risk model for the pathogenesis of SIDS proposed by us. According to this model, sudden death in SIDS results from the intersection of three overlapping factors: (1) a vulnerable infant; (2) a critical developmental period in homeostatic control, and (3) an exogenous stressor(s). An infant will die of SIDS only if he/she possesses all three factors; the infant’s vulnerability lies latent until he/she enters the critical period and is subject to an exogenous stressor. According to this model, heterogeneous disorders may make the infant vulnerable to sudden death during the critical period, as potentially exemplified by two previously reported lesions in SIDS brains (arcuate nucleus hypoplasia and subtle hypomyelination). Nevertheless, the triple-risk model does not preclude the possibility that the majority of SIDS deaths will be explained by a single common pathway upon which multiple stressors impinge to produce sudden death during the critical period.

© 1994 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Control of Breathing during Development

Published online: September 30, 2009
Issue release date: 1994

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO


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