Neonatology
Original Paper
Brain Blood Flow Responses to Indomethacin during Hemorrhagic Hypotension in Newborn PigletsLouis P.T.a,f,i · Yamashita Y.a,g · Del Toro J.a,f · Michael L.H.b,c,h · Contant C.F.d · Goddard-Finegold J.a,e,gDepartments of aPediatrics, bMedicine, cPhysiology, dNeurosurgery, ePathology, Divisions of fCritical Care Medicine, gPediatric Neurology, hCardiovascular Sciences, iEmergency Medicine, Texas Children’s Hospital, The Cain Foundation Research Laboratories, and the Debakey Heart Center of the Methodist Hospital, Baylor College of Medicine, Houston, Tex., USA
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Article / Publication Details
Published online: September 30, 2009
Issue release date: 1994
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
Abstract
Indomethacin has been shown to reduce cerebral blood flow and cerebral blood flow velocities in newborn infants and animals of various species. To answer the question of whether there may be a compromise of cerebral perfusion in hypotensive infants who have been treated with indomethacin, cerebral blood flow and cerebral vascular resistance were determined in 10 control and 16 indomethacin-treated 1-day-old piglets during (1) steady state conditions; (2) 10 min after the administration of saline or a 0.2-mg/kg dose of indomethacin; (3) 1 h after saline or indomethacin administration, and (4) 10 min after induction of moderate hemorrhagic hypotension. Mean arterial blood pressures increased immediately after the infusion of indomethacin in the experimental group. Cerebral blood flows did not change throughout the study despite hemorrhagic hypotension in controls; cerebral blood flows were significantly decreased 10 min after indomethacin infusion in the experimental animals. However, total and regional cerebral blood flows were not further decreased in the presence of moderate hypotension. Cerebral vascular resistance increased 10 min after indomethacin infusion but returned to steady state 1 h following the indomethacin dose. These results suggest that indomethacin lowers baseline cerebral blood flow, but does not impair cerebrovascular regulatory responses during acute, moderate hemorrhagic hypotension in the newborn piglet.
© 1994 S. Karger AG, Basel
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Article / Publication Details
Published online: September 30, 2009
Issue release date: 1994
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
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