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Modeling Hepatitis C Virus Therapies Combining Drugs and Lectin Affinity Plasmapheresis

Tullis R.H.a · Duffin R.P.a · Ichim T.E.b · Joyce J.A.a · Levin N.W.c

Author affiliations

aAethlon Medical Inc. and bMedistem Inc., San Diego, Calif., and cRenal Research Institute, New York, N.Y., USA

Corresponding Author

Richard H. Tullis, PhD

Aethlon Medical Inc., 3030 Bunker Hill Street

San Diego, CA 92109 (USA)

Tel. +1 858 459 7800, ext. 304, Fax +1 858 272 2738

E-Mail rhtullis@aethlonmedical.com

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Blood Purif 2010;29:210–215

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Hepatitis C virus (HCV) infection can be cured by standard pegylated interferon (IFN) + ribavirin drug therapy in 30–50% of treatment-naïve genotype 1 HCV patients. Cure rate is defined as a sustained viral response measured 6 months after the end of treatment. Recently, Fujiwara et al. [Hepatol Res 2007;37:701–710], using a double-filtration plasmapheresis (DFPP) technique, showed that simple physical reduction in circulating HCV using a 1-week pretreatment increased the cure rate for treatment-naïve type 1 HCV patients from 50 (controls) to 78% (treated). For previous nonresponders, the cure rate increased from 30 to 71%. This effect occurs even though the DFPP per treatment HCV viral load reduction averaged 26%. In clinical studies discussed here, a lectin affinity plasmapheresis (LAP) device caused an estimated 41% decrease in viral load as previously reported. A more detailed analysis using normalized data to correct for any variations in initial viral load gave an average 29% per treatment viral load reduction in 5 HCV-positive dialysis patients. The latter data indicate that continuous application of LAP could bring HCV viral load to undetectable levels in 4.1 days. Compared to DFPP, the LAP approach has the advantage that no plasma losses are incurred. In addition hemopurification can be carried out for extended periods of time analogous to continuous renal replacement therapy for the treatment of acute kidney failure, making the process much more effective. Calculations based on these data predict that continuous hemopurification would substantially increase the rate of viral load reduction (approx. 14-fold) and therefore increase the cure rate for HCV standard-of-care drug therapies without adding additional drugs and their associated side effects.

© 2010 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: January 08, 2010
Issue release date: January 2010

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)

For additional information: http://www.karger.com/BPU

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