Pharmacology and Treatment
Inhibition of Elicitation of Contact Dermatitis in Humans by Mometasone Furoate: Evaluation by Means of 20-MHz B Scanning Associated with Image AnalysisDi Nardo A. · Giusti G. · Mantovani L. · Bianchi B. · Seidenari S.
Department of Dermatology, University of Modena, Italy
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Article / Publication Details
Background: Mometasone furoate (MF) is a new strongly lipophilic steroid which has an anti-inflammatory effect as evaluated by in vivo and in vitro studies. Objective: The objective of the present study was to investigate the degree of inhibition of experimental allergic contact dermatitis induced by the treatment with MF. Methods: The therapeutic effect was evaluated by an echographic method associated with image analysis. MF activity was compared to that of hydrocortisone acetate 0.5% (Cortaid Cream, Lachifarma), clobetasone butyrate 0.05% (Eumovate Cream, Glaxo) and clobetasol propionate 0.05% (Clobesol Cream, Glaxo), classified respectively as weak, moderately potent and very potent steroids. Results: The different corticosteroid formulations employed for inhibiting experimentally induced contact dermatitis reflect the expected rank order of efficacy. Conclusion: MF behaves like clobetasol butyrate ranking as a moderately potent corticosteroid.
© 1997 S. Karger AG, Basel
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