The present review summarizes the basic cytogenetic information available pertaining to the most important Bovidae species, namely cattle, buffalo, sheep and goat, with the aim of tracing their evolutionary relationships and to provide – for the first time – the hypothetical ancestral karyotype of the Bovinae-Caprinae subfamilies, also in relation to the other nondomestic species which are included in this important taxonomic family. Evolution of the Bovinae-Caprinae autosomes and gonosomes is discussed on the basis of the most recent advances in chromosome banding, linkage studies, FISH-mapping and molecular information.

1.
Adega F, Guedes-Pinto H, Chaves R: Satellite DNA in the karyotype evolution of domestic animals. Clinical considerations. Cytogenet Genome Res, this issue (2009).
2.
Amaral MEJ, Grant JR, Riggs PK, Stafuzza NB, Rodrigues Filho EA, et al: A first generation whole genome RH map of the river buffalo with comparison to domestic cattle. BMC Genomics 9:631 (2008).
3.
Bahri-Darwich I, Cribiu EP, Berland HM, Darré R: A new Robertsonian translocation in Blonde d’Aquitaine cattle, rob(4;10). Genet Sel Evol 25:413–419 (1993).
4.
Balmus G, Trifonov VA, Biltueva LS, O’Brien PCM, Alkalaeva ES, et al: Cross-species chromosome painting among camel, cattle, pig and human: further insights into the putative Cetartiodactyla ancestral karyotype. Chromosome Res 15:499–514 (2007).
5.
Berland HM, Sharma A, Cribiu EP, Darre R, Boscher J, Popescu CP: A new case of a Robertsonian translocation in cattle. J Hered 79:33–36 (1988).
6.
Bongso A, Basrur PK: Chromosome anomalies in Canadian Guernsey bulls. Cornell Vet 66:476–489 (1976).
7.
Bouvet A, Popescu CP, de Giovanni-Macchi AM, Colombo G, Molteni L: Synaptonemal complexes analysis in a bull carrying a 4;8 Robertsonian translocation. Ann Génét 32:193–199 (1989).
8.
Buckland RA, Evans HJ: Cytogenetic aspects of phylogeny in the Bovidae. I-G-banding. Cytogenet Cell Genet 21:42–63 (1978).
9.
Bunch TD, Nadler CF: Giemsa band-patterns of the tahr and chromosomal evolution of the tribe Caprini. J Hered 71:110–116 (1980).
10.
Bunch TD, Foote WC, Spillett JJ: Translocations of acrocentric chromosomes and their implications in the evolution of sheep (Ovis). Cytogenet Cell Genet 17:122–136 (1976).
11.
Bunch TD, Wu C, Zhang YP, Wang S: Phylogenetic analysis of snow sheep (Ovis nivicola) and closely related taxa. J Hered 97:21–30 (2006).
12.
Capanna E: Chromosomal evolution in mice: thirty years after. Ann Génétique 46:73–74 (2003).
13.
Chaves R, Adega F, Santos S, Guedes-Pinto H, Heslop-Harrison JS: In situ hybridization and chromosome banding in mammalian species. Cytogenet Genome Res 96:113–116 (2002).
14.
Chaves R, Guedes-Pinto H, Heslop-Harrison JS: Phylogenetic relationships and the primitive X chromosome inferred from chromosomal and satellite DNA analysis in Bovidae. Proc Biol Sci 272:2009–2016 (2005).
15.
Chessa B, Pereira F, Arnaud F, Amorim A, Goyache F, et al: Revealing the history of sheep domestication using retrovirus integrations. Science 324:532–536 (2009).
16.
Cribiu EP, Matejka M, Darre R, Durand V, Berland HM, Bouvet A: Identification of chromosomes involved in a Robertsonian translocation in cattle. Genet Sel Evol 21:555–560 (1989).
17.
CSKBB: Standard karyotype of the river buffalo (Bubalus bubalis L., 2n = 50). Report of the committee for the standardization of banded karyotypes of the river buffalo. Cytogenet Cell Genet 67:102–113 (1994).
18.
de Gortari MJ, Freking BA, Cuthbertson RP, et al: A second generation linkage map of the sheep genome. Mamm Genome 9:204–209 (1998).
19.
Di Berardino D, Iannuzzi L: Chromosome banding homologies in swamp and murrah buffalo. J Hered 72:183–189 (1981).
20.
Di Berardino D, Iannuzzi L, Ferrara L, Matassino D: A new case of Robertsonian translocation in cattle. J Hered 70:436–438 (1979).
21.
Di Berardino D, Iannuzzi L, Bettini TM, Matassino D: Ag-NOR variation and banding homologies in two species of Bovidae. Can J Genet Cytol 23:89–99 (1981).
22.
Di Meo GP, Molteni L, Perucatti A, de Giovanni AM, Incarnato D, et al: Chromosomal characterization of three centric fusion translocations in cattle using G-, R-, and C-banding and FISH technique. Caryologia 53:213–218 (2000).
23.
Di Meo GP, Perucatti A, Floriot S, Incarnato D, Rullo R, et al: Chromosome evolution and improved cytogenetic maps of the Y chromosome in cattle, zebu, river buffalo, sheep and goat. Chromosome Res 13:349–355 (2005).
24.
Di Meo GP, Gallagher DS, Perucatti A, Wu X, Incarnato D, et al: Mapping of 11 genes by FISH to BTA2, BBU2q, OAR2q and CHI2, and comparison with HSA2q. Anim Genet 37:299–300 (2006a).
25.
Di Meo GP, Perucatti A, Chaves R, Adega F, De Lorenzi L, et al: Cattle rob(1;29) originating from complex chromosome rearrangements as revealed by both banding and FISH-mapping techniques. Chomosome Res 14:649–655 (2006b).
26.
Ducos A, Revay T, Kovacs A, Hidas A, Pinton A, et al: Cytogenetic screening of livestock populations in Europe: an overview. Cytogenet Genome Res 120:26–41 (2008).
27.
Dyrendhal I, Gustavsson I: Sexual functions, semen characteristics and fertility of bulls carrying the 1/29 chromosome translocation. Hereditas 90:281–289 (1979).
28.
Eldridge FE: High frequency of a Robertsonian translocation in a herd of British White cattle. Vet Record 97:71–73 (1975).
29.
Ellsworth SM, Paul SR, Bunch TD: A 14/28 dicentric Robertsonian translocation in a Holstein cow. Theriogenology 11:165–171 (1979).
30.
Fries R, Ruvinsky A (eds): The Genetics of Cattle, pp 247–327 (CABI Publishing, New York 1999).
31.
Gallagher DS, Womack JE: Chromosome conservation in the Bovidae. J Hered 83:287–298 (1992).
32.
Gallagher DS, Derr JN, Womack JE: Chromosome conservation among the advanced pecorans and determination of the primitive bovid karyotype. J Hered 85:204–210 (1994).
33.
Gallagher DS, Davis SK, De Donato M, Burzlaff JD, Womack JE, et al: A molecular cytogenetic analysis of the tribe Bovini (Artiodactyla: Bovidae: Bovinae) with an emphasis on sex chromosome morphology and NOR distribution. Chromosome Res 7:481–492 (1999).
34.
Gustavsson I: Cytogenetics, distribution and phenotypic effects of a translocation in Swedish cattle. Hereditas 63:68–169 (1969).
35.
Gustavsson I, Rockborn G: Chromosome abnormality in three cases of lymphatic leukaemia in cattle. Nature 203:990 (1964).
36.
Hayes H, Petit E, Dutrillaux B: Comparison of RBG-banded karyotypes of cattle, sheep, and goats. Cytogenet Cell Genet 57:51–55 (1991).
37.
Holecková B, Sutiaková I, Pijáková N: Robertsonian translocation in a cattle population. Vet Medicína 40:33–34 (1995).
38.
Iannuzzi L, Di Meo GP: Chromosomal evolution in bovids: a comparison of cattle, sheep and goat G- and R-banded chromosomes and cytogenetic divergences among cattle, goat and river buffalo sex chromosomes. Chromosome Res 3:291–299 (1995).
39.
Iannuzzi L, Di Berardino D, Gustavsson I, Ferrara L, Di Meo GP: Centromeric loss in translocations of centric fusion type in cattle and water buffalo. Hereditas 106:73–81 (1987).
40.
Iannuzzi L, Di Meo GP, Perucatti A, Ferrara L: A comparison of G- and R-banding in cattle and river buffalo prometaphase chromosomes. Caryologia 43:283–290 (1990).
41.
Iannuzzi L, Rangel-Figueiredo T, DiMeo GP, Ferrara L: A new Robertsonian translocation in cattle, rob(15;25). Cytogenet Cell Genet 59:280–283 (1992).
42.
Iannuzzi L, Rangel-Figueiredo T, Di Meo GP, Ferrara L: A new centric fusion translocation in cattle, rob(16;18). Hereditas 119:239–243 (1993).
43.
Iannuzzi L, Di Meo GP, Perucatti A: Identification of nucleolus organizer chromosomes and frequency of active NORs in river buffalo (Bubalus bubalis L.). Caryologia 49:27–34 (1996).
44.
Iannuzzi L, Ferretti L, Di Meo GP, Perucatti A: FISH-mapping of bovine U21, U1 and U7 molecular markers to river buffalo chromosomes 3p, 5q and 5p. Chromosome Res 5:337–340 (1997).
45.
Iannuzzi L, Di Meo GP, Perucatti A, Incarnato D, Schibler L, et al: Comparative FISH-mapping of bovid X chromosomes reveals homologies and divergences between the subfamilies Bovinae and Caprinae. Cytogenet Cell Genet 89:171–176 (2000).
46.
Iannuzzi L, Di Meo GP, Perucatti A, Schibler L, Incarnato D, et al: Comparative FISH-mapping in river buffalo and sheep chromosomes: assignment of forty autosomal type I loci from sixteen human chromosomes. Cytogenet Cell Genet 94:43–48 (2001).
47.
Iannuzzi L, Di Meo GP, Perucatti A, Schibler L, Incarnato D, et al: The river buffalo (Bubalus bubalis, 2n = 50) cytogenetic map: assignment of 64 loci by fluorescence in situ hybridisation and R-banding. Cytogenet Genome Res 102:65–75 (2003).
48.
ISCNDB 2000: International System for Chromosome Nomenclature of Domestic Bovids. Di Berardino D, Di Meo GP, Gallagher DS, Hayes H, Iannuzzi L (co-ordinator) (eds). Cytogenet Cell Genet 92:283–299 (2001).
49.
Kovács A, Papp M: Report on chromosomal examination of A.I. bulls in Hungary. Ann Génét Sél Anim 9:528 (1977).
50.
Logue DN, Harvey MJ: A 14/20 Robertsonian translocation in Swiss Simmental cattle. Res Vet Sci 25:7–12 (1978).
51.
Lojda L, Rubes J, Staviková M, Huvránková J: Chromosomal findings in some reproductive disorders in bulls. Proceedings of the 8th International Congress on Animal Reproduction and Artificial Insemination, Krakow, Poland, p 158 (1976).
52.
Long S: Centric fusion translocations in cattle: a review. Vet Rec 116:516–518 (1985).
53.
Matthee CA, Davis SK: Molecular insights into the evolution of the family Bovidae: a nuclear DNA perspective. Mol Biol Evol 18:1220–1230 (2001).
54.
Miyake Y, Kaneda Y: A new type of Robertsonian translocation (1/26) in a bull with unilateral cryptorchidism, probably occurring de novo. Nippon Juigaku Zasshi 49:1015–1019 (1987).
55.
Miyake Y, Murakami RK, Kaneda Y: Inheritance of the Robertsonian translocation (1/21) in Holstein-Friesian cattle I. Chromosome analysis. J Vet Med Sci 53:113–116 (1991).
56.
Molteni L, de Giovanni-Macchi AM, Succi G, Cremonesi F, Stacchezzini S, et al: A new centric fusion translocation in cattle: rob(13;19). Hereditas 129:177–180 (1998).
57.
Molteni L, Meggiolaro D, de Giovanni-Macchi AM, De Lorenzi L, Crepaldi P, et al: Fertility of cryopreserved sperm in three bulls with different Robertsonian translocations. Anim Reprod Sci 86:27–36 (2005).
58.
Nguyen TT, Aniskin VM, Gerbault-Seureau M, Planton H, Renard JP, et al: Phylogenetic position of the saola (Pseudoryx nghetinhensis) inferred from cytogenetic analysis of eleven species of Bovidae. Cytogenet Genome Res 122:41–54 (2008).
59.
Nicodemo D, Castello A, Pauciullo A, Cosenza G, Ramunno L, et al: Proc. XVIII A.S.P.A. National Congress, Palermo (Italy), pp 9–12 June (2009).
60.
Papp M, Kovács A: 5/18 dicentric Robertsonian translocation in a Simmental bull. Proceedings of the 4th European Colloquium Cytogenetics of Domestic Animals, Uppsala, Sweden, pp 51–54 (1980).
61.
Pearce PD, Ansari HA, Maher DW, Amarante MR, Monro TL, Hendrikse WL: 1/25 translocations in Blonde d’Aquitaine cattle in New Zealand. N Z Vet J 45:69–71 (1997).
62.
Pinton A, Ducos A, Berland HM, Séguéla A, Blanc MF, Darré A, Mimar S, Darré R: A new Robertsonian translocation in Holstein-Friesian cattle. Genet Sel Evol 29:523–526 (1997).
63.
Piumi F, Schibler L, Vaiman D, Oustry A, Cribiu EP: Comparative cytogenetic mapping reveals chromosome rearrangements between the X chromosomes of two closely related mammalian species (cattle and goats). Cytogenet Cell Genet 81:36–41 (1998).
64.
Ponce de Leon FA, Ambady S, Hawkins GA, Kappes SM, Bishop MD, et al: Development of a bovine X chromosome linkage group and painting probes to assess cattle, sheep, and goat X chromosome segment homologies. Proc Natl Acad Sci USA 93:3450–3454 (1996).
65.
Popescu CP: A new type of Robertsonian translocation in cattle. J Hered 68:138–142 (1977).
66.
Popescu CP, Pech A: Une bibliographie sur la translocation 1/29 de bovins dans le monde (1964–1990). Annal Zootechnie 40:271–305 (1991).
67.
Robertson WRB: Chromosome studies. I. Taxonomic relationships shown in the chromosomes of Tettigidae and Acrididae. V-shaped chromosomes and their significance in Acrididae, Locustidae and Gryllidae: chromosome and variation. J Morph 27:179–331 (1916).
68.
Robinson TJ, Harrison WR, Ponce de León FA, Davis SK, Elder FF: A molecular cytogenetic analysis of X chromosome repatterning in the Bovidae: transpositions, inversions, and phylogenetic inference. Cytogenet Cell Genet 80:179–184 (1998).
69.
Rubes J, Musilová P, Borkovec L, Borkovcová Z, Svecová D, Urbanová J: A new Robertsonian translocation in cattle, rob(16;20). Hereditas 124:275–279 (1996).
70.
Rybar R, Horakova J, Machatkova M, Hanzalova K, Rubes J: Embryos produced in vitro from bulls carrying 16;20 and 1;29 Robertsonian translocations: Detection of translocations in embryos by fluorescence in situ hybridization. Zygote 13:31–34 (2005).
71.
Schmutz SM, Moker JS, Pawlyshyn V, Haugen B, Clark EG: Fertility effects of the 14;20 Robertsonian translocation in cattle. Theriogenology 47:815–823 (1997).
72.
Slota E, Switonski M: A new Robertsonian translocation 5;22 in cattle. Studies of banded chromosomes and synaptonemal complexes. Genetica Polonica 33:227–231 (1992).
73.
Tanaka K, Matsuda Y, Masangkay JS, Solis CD, Anunciado RVP, et al: Characterization and chromosomal distribution of satellite DNA sequences of the water buffalo, Bubalus bubalis. J Hered 90:418–422 (1999).
74.
Tanaka K, Matsuda Y, Masangkay JS, Solis CD, Anunciado RVP, et al: Cytogenetic analysis of the tamaraw (Bubalus mindorensis): a comparison of R-banded karyotype and chromosomal distribution of centromeric satellite DNAs, telomeric sequence, and 18S-28S rRNA genes with domestic water buffaloes. J Hered 91:117–121 (2000a).
75.
Tanaka K, Yamamoto Y, Amano T, Yamagata T, Dang VB, et al: Robertsonian translocation, rob(2;28), found in Vietnamese cattle. Hereditas 133:19–23 (2000b).
76.
Tateno H, Miyake YI, Mori H, Kamiguchi Y, Mikamo K: Sperm chromosome study of two bulls heterozygous for different Robertsonian translocations. Hereditas 120:7–11 (1994).
77.
White MJD: Animal Cytology and Evolution. 3rd ed. (Cambridge University Press, Cambridge 1973).
78.
Wurster DH, Benirscke K: Chromosome studies in the superfamily Bovidae. Chromosoma 25:152–171 (1968).
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