Dermatology

Clinical and Laboratory Investigation

Progressive Systemic Sclerosis Associated with Multiple Mononeuropathy

Nitta Y.a · Sobue G.b

Author affiliations

aDepartment of Dermatology and bFourth Department of Internal Medicine, Aichi Medical University, Aichi, Japan

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Dermatology 1996;193:22–26

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Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigation

Received: June 26, 1995
Accepted: January 12, 1996
Published online: October 06, 2009
Issue release date: 1996

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM

Abstract

Background: Progressive systemic sclerosis (PSS) is a chronic connective tissue inflammatory disease which commonly attacks the skin and the visceral organs, but rarely the peripheral nervous system. Objective: The aim of this study was to investigate PSS accompanied by peripheral neuropathy clinically, electrophysiologically and pathologically from a sural nerve biopsy. Methods: Two women suffering from PSS but without any other collagen disease were studied. Both patients developed peripheral neuropathy with multiple mononeuropathy of the limbs, and in one woman, in the trunk as well. Results: A biopsy of the sural nerve revealed axonal and myelin segmental degeneration, loss of large myelinated fibers and an increase of collagen fibers, but there was no evidence of vasculitis. An electron microscopic examination revealed degenerated axons, disrupted myelin sheaths and multilayered basal lamina in the capillaries. Conclusion: Mononeuropathy in PSS suggests that ischemic neuropathy may be related to the immune-mediated vasculopathy.

© 1996 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigation

Received: June 26, 1995
Accepted: January 12, 1996
Published online: October 06, 2009
Issue release date: 1996

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM


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