Pharmacology and Treatment
Safety and Effectiveness of an Aggressive and Individualized Bath-PUVA Regimen in the Treatment of PsoriasisCalzavara-Pinton P.G.a · Ortel B.b · Hönigsmann H.b · Zane C.a · de Panfilis G.a
a Department of Dermatology, Brescia University Hospital, Brescia, Italy; b Division of Special and Environmental Dermatology, University of Vienna, Austria
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Background: The optimal therapeutic regimen of bath-PUVA therapy of psoriasis is still under debate. Objective: We investigated the safety and efficacy of an aggressive and individualized bath-PUVA regimen. Methods: Two closely matched groups of 22 psoriatic patients were treated either with 30-min baths in 0.0003% 8-methoxypsoralen (8-MOP) aqueous solution or oral administration of the drug. According to the standard European regimen, treatments were delivered 4 times a week starting with the minimal phototoxic dose. Results: Complete clearing or marked improvement was observed in all the patients. However, with bath-PUVA, the same therapeutic effect required smaller cumulative UVA doses (39.3 ± 15.8 vs. 123.8 ± 39.9 J/cm2) and lower numbers of exposures (15.2 ± 4.4 vs. 20.6 ± 4.2). Both differences were significant at the 0.01 level (Student’s t test). Gastrointestinal side effects were of course restricted to oral 8-MOP. The incidences of burns and pruritus were similar. Conclusion: Using an aggressive and individualized schedule, bath-PUVA therapy showed a greater efficacy than oral PUVA therapy while being just as safe.
© 1994 S. Karger AG, Basel
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