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Pharmacology and Treatment

Safety and Effectiveness of an Aggressive and Individualized Bath-PUVA Regimen in the Treatment of Psoriasis

Calzavara-Pinton P.G.a · Ortel B.b · Hönigsmann H.b · Zane C.a · de Panfilis G.a

Author affiliations

a Department of Dermatology, Brescia University Hospital, Brescia, Italy; b Division of Special and Environmental Dermatology, University of Vienna, Austria

Related Articles for ""

Dermatology 1994;189:256–259

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Article / Publication Details

First-Page Preview
Abstract of Pharmacology and Treatment

Received: July 16, 1993
Accepted: January 10, 1994
Published online: October 07, 2009
Issue release date: 1994

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM

Abstract

Background: The optimal therapeutic regimen of bath-PUVA therapy of psoriasis is still under debate. Objective: We investigated the safety and efficacy of an aggressive and individualized bath-PUVA regimen. Methods: Two closely matched groups of 22 psoriatic patients were treated either with 30-min baths in 0.0003% 8-methoxypsoralen (8-MOP) aqueous solution or oral administration of the drug. According to the standard European regimen, treatments were delivered 4 times a week starting with the minimal phototoxic dose. Results: Complete clearing or marked improvement was observed in all the patients. However, with bath-PUVA, the same therapeutic effect required smaller cumulative UVA doses (39.3 ± 15.8 vs. 123.8 ± 39.9 J/cm2) and lower numbers of exposures (15.2 ± 4.4 vs. 20.6 ± 4.2). Both differences were significant at the 0.01 level (Student’s t test). Gastrointestinal side effects were of course restricted to oral 8-MOP. The incidences of burns and pruritus were similar. Conclusion: Using an aggressive and individualized schedule, bath-PUVA therapy showed a greater efficacy than oral PUVA therapy while being just as safe.

© 1994 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Pharmacology and Treatment

Received: July 16, 1993
Accepted: January 10, 1994
Published online: October 07, 2009
Issue release date: 1994

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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