Dermatology
Pharmacology and Treatment
Topical Alpha-lnterferon Ointment with Dimethyl Sulfoxide in the Treatment of Recurrent Genital Herpes simplexShupack J. · Stiller M. · Davis I. · Kenny C. · Jondreau L.Section of Dermatopharmacology, Department of Dermatology, New York University Medical Center, New York, N.Y., USA
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Article / Publication Details
Received: February 21, 1991
Accepted: June 05, 1991
Published online: October 08, 2009
Issue release date: 1992
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)
For additional information: https://www.karger.com/DRM
Abstract
The recent in vivo appearance of acyclovir-resistant strains of herpes simplex virus stresses the need for new therapeutic agents to combat this common virus. Topical interferon preparations may help fill this void. In the present study dimethyl sulfoxide was combined with α-interferon in an ointment base to increase percutaneous penetration. In this double-blind, placebo-controlled trial, patients with recurrent genital herpes simplex using the topical α-interferon preparation had a more rapid cessation of viral shedding when compared to the placebo group (66% culture negative on day 1 vs. 25% of placebo patients; p < 0.02). In the 90-day post-treatment period, interferon-treated patients had fewer recurrences than their placebo-treated counterparts (1.18 vs. 2.25). This reduction while not statistically significant was encouraging (p < 0.10).
© 1992 S. Karger AG, Basel
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Article / Publication Details
Received: February 21, 1991
Accepted: June 05, 1991
Published online: October 08, 2009
Issue release date: 1992
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)
For additional information: https://www.karger.com/DRM
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