Pharmacology and Treatment
Systemic Therapy of Advanced Metastatic Malignant Melanoma with a Combination of Fibroblast Interferon-β and Recombinant Interferon-γKowalzick L. · Weyer U. · Lange P. · Breitbart E.W.
Universitäts-Hautklinik und Poliklinik Hamburg, BRD
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Article / Publication Details
Eighteen patients with advanced metastatic malignant melanoma (stage IV UICC1987) were entered into a prospective trial with a combination of systemic fibroblast interferon-β and recombinant interferon-γ. Treatment was performed over a 6-week period with 3 × 5 × 106 U i.v. interferon-β and 5 × 100 μg s.c. interferon-γ every week. Under this therapy 16 patients showed a progressive disease, and 2 patients had a stable disease. The median time of survival was 7.5 months. Successive immunological examinations showed no significant immunomodulating effect after the 6 weeks of interferon treatment. We conclude that the combination of interferon-β and -γ is insufficient in the treatment of advanced metastatic malignant melanoma when administered by this dose, route and schedule.
© 1999 S. Karger AG, Basel
Article / Publication Details
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