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Clinical and Laboratory Investigation

Diseased Skin Models in the Hairless Guinea Pig: in vivo Percutaneous Absorption

Moon K.C.a,b · Wester R.C.b · Maibach H.I.b

Author affiliations

aDepartment of Dermatology, University of California School of Medicine, San Francisco, Calif.. USA; bDepartment of Dermatology, Korea University College of Medicine, Seoul, Korea

Related Articles for ""

Dermatologica 1990;180:8–12

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Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigation

Received: July 07, 1989
Accepted: August 10, 1989
Published online: October 08, 2009
Issue release date: 1990

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM

Abstract

We observed hydrocortisone and benzoic acid absorption in relation to experimentally induced in vivo damaged skin models in the hairless guinea pig. Radioactivity of the drugs in urine was calculated as absorbed dose. Both drugs have different patterns of excretion in urine. D amaging the skin abolished some barrier function and increased the absorption of both model drugs. With cellophane-tape-stripped skin, the absorption was increased 3 times and 2 times for each drug, respectively. Irritation with 2% sodium lauryl sulfate increased absorption by a ratio of 2–4 times. Defatting with chloroform/methanol (2:1) mixture increased absorption to the greatest extent (5- and 2.7-fold). The possible mechanism of a delipidization effect was considered in view of a visible skin lesion and inflammatory reaction. Precautions are proposed for those with damaged/diseased skin in dealing with topical medications or handling solvents.

© 1999 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigation

Received: July 07, 1989
Accepted: August 10, 1989
Published online: October 08, 2009
Issue release date: 1990

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM


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