Dermatology

Case Report

Reticulate Pigmentation due to Bleomycin: Light- and Electron-Microscopic Studies

Wright A.L.a · Bleehen S.S.a · Champion A.E.b

Author affiliations

Departments of aDermatology and bRadiotherapy and Oncology, Royal Hallamshire Hospital and Weston Park Hospital, Sheffield, UK

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Dermatologica 1990;180:255–257

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Article / Publication Details

First-Page Preview
Abstract of Case Report

Received: December 12, 1988
Accepted: June 23, 1989
Published online: October 08, 2009
Issue release date: 1990

Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM

Abstract

An unusual case of extensive reticulate pigmentation due to bleomycin is reported. Light- and electron-microscopic studies showed a marked increase of melanin pigment in the basal keratinocytes and a number of melanophages in the upper dermis. The number of melanocytes appeared to be normal. Electron microscopy also revealed damage to subcellular organelles. The increase in pigmentation is thought to be a consequence of this focal damage.

© 1999 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Case Report

Received: December 12, 1988
Accepted: June 23, 1989
Published online: October 08, 2009
Issue release date: 1990

Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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