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Short Communication

Full or Near Full Length Nucleotide Sequences of TT Virus Variants (Types SANBAN and YONBAN) and the TT Virus-Like Mini Virus

Takahashi K.a · Hijikata M.a · Samokhvalov E.I.b · Mishiro S.a

Author affiliations

aDepartment of Medical Sciences, Toshiba General Hospital, Tokyo, Japan; bD.I. Ivanovsky Institute of Virology, Moscow, Russia

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Intervirology 2000;43:119–123

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Article / Publication Details

First-Page Preview
Abstract of Short Communication

Published online: August 28, 2000
Issue release date: August 2000

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 1

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: https://www.karger.com/INT

Abstract

TT virus (TTV) is a common virus and consists of many genotypes and variants. In addition, there exists a virus which both differs greatly from and retains a considerable resemblance to TTV, such as the TTV-like mini virus (TLMV) as we reported previously. Here we report the near full length genomic sequences of 4 isolates of a new variant of TTV (designated YONBAN) along with the full length sequences of 2 isolates of the TTV-SANBAN lineage and 7 isolates of the TLMV species derived from human sera. The TTV-YONBAN sequences showed only about 50% identity at the nucleotide level to those of the prototype TTV (TA278) and to SANBAN, and even less to TLMV. Moreover, the ORF1 of YONBAN lacked the ATG initiation codon which is shared by all the TTV and TLMV isolates so far identified in humans; instead, YONBAN had a Kozak’s rule-compatible ACG codon as the candidate initiation site for the ORF1 translation. Nevertheless, the overall genetic structure and the conserved amino acid motifs within the ORF1 and the ORF2 were well shared among the prototype TTV strains, the SANBAN and YONBAN variants, and TLMV. The most conserved nucleotide sequence was found in the noncoding region just upstream from the ORF2, allowing construction of a phylogenetic tree which implied that the TTV genotypes and variants, the TLMV, and chicken anemia virus could be coclassified under a superfamily for which we proposed the name of ‘Paracircoviridae’ in our previous report.

© 2000 S. Karger AG, Basel


References

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    External Resources
  6. Takahashi K, Iwasa Y, Hijikata M, Mishiro S: Identification of a new human DNA virus (TTV-like mini virus, TLMV) intermediately related to TT virus and chicken anemia virus. Arch Virol, in press.
  7. Mushahwar IK, Erker JC, Muerhoff AS, Leary TP, Simons JN, Birkenmeyer LG, Chalmers ML, Pilot-Matias TJ, Desai SM: Molecular and biophysical characterization of TT virus: Evidence for a new virus family infecting humans. Proc Natl Acad Sci USA 1999;96:3177–3182.
  8. Kozak M: Structural features in eukaryotic mRNAs that modulate the initiation of translation. J Biol Chem 1991;266:19867–19870.

Article / Publication Details

First-Page Preview
Abstract of Short Communication

Published online: August 28, 2000
Issue release date: August 2000

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 1

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: https://www.karger.com/INT


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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