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Review Article

Impacts of Vaccination on Hepatitis B Viral Infections in Korea over a 25-Year Period

Park N.H.a · Chung Y.-H.b · Lee H.-S.c

Author affiliations

aDepartment of Internal Medicine and Biomedical Research Center, Ulsan University Hospital, University of Ulsan College of Medicine, and bDepartment of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Ulsan, and cDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea

Corresponding Author

Young-Hwa Chung, MD

Asan Medical Center, University of Ulsan College of Medicine

388-1 Pungnap-2 dong

Songpa-gu, Seoul 138-736 (Korea)

Tel. +82 2 3010 3184, Fax +82 2 476 0824, E-Mail yhchung@amc.seoul.kr

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Intervirology 2010;53:20–28

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Abstract

Background: Hepatitis B virus (HBV) vaccination has effectively reduced the acute and chronic infection rates in recent years. Since 1983, HBV vaccination has been recommended for all neonates in Korea. Methods: This article reviews the impacts of HBV vaccination throughout the past 25 years in Korea. Before the introduction of the HBV vaccination program, approximately 8% of the general Korean population tested positive for hepatitis B virus surface antigen (HBsAg). Results: The percentage of vaccinated infants has surpassed 98.9% since 1990. The HBsAg carrier rate in the general population decreased to 3.7% in 2007. In particular, the prevalence of HBsAg decreased to 0.44% in teenagers and to 0.2% in children younger than 10 years. In addition, administration of the HBV vaccine may have reduced the risk of hepatocellular carcinoma among adults. Despite the administration of hepatitis B immunoglobulin and the HBV vaccine to children with HBsAg-positive mothers, the failure rate of HBV immunoprophylaxis was 4.2% in 2008. In Korea, there have been no reported cases of HBV surface gene variants such as G145R. Conclusions: The prevalence of HBV carriers in Korea was markedly reduced after the introduction of the universal HBV vaccination program. Korea is now classified as an area of intermediate endemicity for HBV.

© 2010 S. Karger AG, Basel


References

  1. Cha C, Dematteo RP: Molecular mechanisms in hepatocellular carcinoma development. Best Pract Res Clin Gastroenterol 2005;19:25–37.
  2. Ganem D, Prince AM: Hepatitis B virus infection: natural history and clinical consequences. N Engl J Med 2004;350:1118–1129.
  3. Goldstein ST, Zhou F, Hadler SC, Bell BP, Mast EE, Margolis HS: A mathematical model to estimate global hepatitis B disease burden and vaccination impact. Int J Epidemiol 2005;34:1329–1339.
  4. Lok AS: Prevention of hepatitis B virus-related hepatocellular carcinoma. Gastroenterology 2004;127:S303–S309.
  5. Korea National Statistical Office: Annual statistical report of causes of death in 2005 (in Korean). 2006.
  6. Kim SR, Kudo M, Hino O, Han KH, Chung CH, Lee HS: Epidemiology of hepatocellular carcinoma in Japan and Korea. Oncology 2008;75:13–16.
  7. Korea National Statistical Office: Annual statistical report of cause of death in 2006 (in Korean). 2007.
  8. Han KH, Kim JK: Liver cancer in Korea. Hepatol Res 2007;37:S106–S109.
  9. Huh K, Choi SY, Whang YS, Lee DS: Prevalence of viral hepatitis markers in Korean patients with hepatocellular carcinoma. J Korean Med Sci 1998;13:306–310.
  10. Cho HH, Kim YH, Jung JM, Cho KH, Cho SH, Choi DH, Jeong SH, Lee JH, Han CJ, Kim YC, Lee JO, Kim CM: Clinical characteristics of non-B, non-C hepatocellular carcinoma and detection of HBV, HCV and TTV viremia (in Korean). Korean J Hepatol 2001;7:439–448.
  11. World Health Organization: Expanded programme on immunization. Global Advisory Group. Weekly Epidemiol Rec 1992;3:11–16.
  12. World Health Organization: Statistics on hepatitis B. www.who.int/immunization_monitoring/diseases/HepB_coverage.jpg
  13. World Health Organization: Vaccines and biologicals: WHO vaccine preventable disease monitoring system: global summary 2009 (data up to 2008). www.who.int/immunization_monitoring/diseases/HepB_map_schedule.jpg
  14. Chen DS: Hepatitis B vaccination: the key towards elimination and eradication of hepatitis B. J Hepatol 2009;50:805–816.
  15. Choe BH: The epidemiology and present status of chronic hepatitis B in Korean children (in Korean). Korean J Pediatr 2008;51:696–703.
    External Resources
  16. Lee CH: Recommended vaccination schedule against hepatitis A and B. Korean J Med 1998;55:715–723.
  17. Korea Institute for Health and Social Affairs: National fertility and family health survey (in Korean). 1994.
  18. Lee SY, Choi BY, Shin YJ, Bang KN, Ki M, Park HB, Yoon JD, Lee KC, Youn BJ: A seroepidemiological study on hepatitis B vaccination program in elemantary school students from Kyonggi-do province (in Korean). Korean J Pediatr Infectious Dis 1997;4:240–256.
  19. Korea Centers for Disease Control and Prevention/Research team for epidemiology: Current state of survey of national immunity (in Korean). 2008.
  20. Park JW, Kim BC, Park JH, Kim WY, Koh YI, Rheu D: A survey of positive rates of HBsAg and anti-HBs in a rural area of Korea (in Korean). Korean J Med 1998;55:176–184.
  21. Kim SJ, Bom HS, Cho KH, Nam KW, Hong KP, Kim JS: A study for HBsAg and anti-HBs positivities in Chonnam and Cheju provincial officials, 1984 (in Korean). Korean J Med 1986;31:313–317.
  22. Chun BY, Lee MK, Rho YK: The prevalence of hepatitis B surface antigen among Koreans by literature review (in Korean). Korean J Epidemiol 1992;14:70–78.
  23. Oh EA, Joung NK: A survey of HBs and anti-HBs positivities among 173,342 primary, middle and high school students in Kwangju City and Chonnam Province (in Korean). Kor J Gastroenterol 1990;22:825–830.
  24. Kim RK, Ahn BM, Lee DS, Lee KM, Park YM, Lee YS, Chung KW, Lee WC, Meng KH: Changes in the positivities of HBsAg and anti-HCV antibody among army draftees in Korea (in Korean). Korean J Hepatol 2000;6:474–480.
  25. Jang MK, Lee JY, Lee JH, Kim YB, Kim HY, Lee MS, Park CK, Yoo JY: Seroepidemiology of HBV infection in South Korea, 1995 through 1999. Korean J Intern Med 2001;16:153–159.
  26. Jang MK, Lee JY, Lee JH, Kim YB, Kim HY, Yoo JY: The investigation for the change of HBsAg positive rate of grade junior high high-schoolers for recent 3 years in Kangwon province (in Korean). Korean J Med 2000;58:608–615.
  27. Korea Centers for Disease Control and Prevention: The Fourth Korea National Health and Nutrition Examination Survey (KNHANES III), 2007. 2008, pp 70–71.
  28. Lee DH, Kim JH, Nam JJ, Kim HR, Shin HR: Epidemiological findings of hepatitis B infection based on 1998 National Health and Nutrition Survey in Korea. J Korean Med Sci 2002;17:457–462.
  29. Ministry of Education, Science and Technology: 2006 report of the sampling analysis results of students’ health examination (in Korean). Yonhap News 2007, pp 9–20.
  30. Sim JG, Seo JK, Suh SJ: Prevalence and its changes of hepatitis B viral markers from 1988 to 1993 in Korean children (in Korean). J Korean Pediatr Soc 1995;38:1535–1539.
  31. An YW, Chung EH, Rheem IS: A study of the current (2003–2005) prevalence of anti-HBs and immunologic memory of hepatitis B vaccine in children from the central area of Korea (in Korean). Korean J Pediatr 2006;49:630–634.
  32. Ahn YO, Kim YS, Lee MS, Shin MH: Hepatitis B virus infection rate among Koreans (in Korean). Seoul J Med 1992;33:105–144.
  33. Song EY, Yun YM, Park MH, Seo DH: Prevalence of occult hepatitis B virus infection in a general adult population in Korea. Intervirology 2009;52:57–62.
  34. Lee HS, Byun JH, Kim CY: Etiology and outcome of acute viral hepatitis in Korean adults. J Korean Med Sci 1990;5:149–154.
  35. Jeong SH: Current status and vaccine indication for hepatitis A virus infection in Korea (in Korean). Korean J Gastroenterol 2008;51:331–337.
    External Resources
  36. Ministry for Health, Welfare and Family Affairs/Korea Centers for Disease Control and Prevention: 2008 Guidebook of Hepatitis B Vertical Transmission Prevention Program (in Korean). 2008, pp 6–16.
  37. Yim HJ, Chang YJ, Byun KS, Suh YS, Kim JH, Kim JY, Yeon JE, Park JJ, Kim JS, Bak YT, Lee CH: The changing patterns of acute hepatitis B infection in Korea in the early 2000s (in Korean). Korean J Med 2005;69:601–607.
  38. Kim IS, Oh HC, Lee Y, Kim JD, Lee WY: Prevalence and changes of HBsAg and anti-HBs for one year period in natural status and after hepatitis B vaccination (in Korean). Korean J Epidemiol 1987;9:40–48.
  39. Park BJ, Ahn YO: Cohort study on the asymptomatic chronic carrier rate of hepatitis B virus among male adults in Korea (in Korean). Korean J Epidemiol 1989;11:263–273.
  40. Chang MH, Chen CJ, Lai MS, Hsu HM, Wu TC, Kong MS, Liang DC, Shau WY, Chen DS: Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. N Engl J Med 1997;336:1855–1859.
  41. Lee MS, Kim DH, Kim H, Lee HS, Kim CY, Park TS, Yoo KY, Park BJ, Ahn YO: Hepatitis B vaccination and reduced risk of primary liver cancer among male adults: a cohort study in Korea. Int J Epidemiol 1998;27:316–319.
  42. Seo K, Park SK, Kim YT, Park O: The prevalence of HBsAg positive parturients in Korea (in Korean). Korean J Obstet Gynecol 2005;48:2119–2124.
  43. Korea Centers for Disease Control and Prevention: Communicable Diseases Monthly Report: Hepatitis B Vertical Transmission Prevention Program (in Korean). 2008, p 14.
  44. Beasley RP, Hwang LY, Lee GC, Lan CC, Roan CH, Huang FY, Chen CL: Prevention of perinatally transmitted hepatitis B virus infections with hepatitis B immune globulin and hepatitis B vaccine. Lancet 1983;2:1099–1102.
  45. Stevens CE, Beasley RP, Tsui J, Lee WC: Vertical transmission of hepatitis B antigen in Taiwan. N Engl J Med 1975;292:771–774.
  46. Chung WK, Yoo JY, Sun HS, LeeHY, Lee IJ, Kim SM, Prince AM: Prevention of perinatal transmission of hepatitis B virus: a comparison between the efficacy of passive and passive-active immunization in Korea. J Infect Dis 1985;151:280–286.
  47. Kim YJ, Kim SK, Park SH, Yang US, Liu BH: A study on distribution of hepatitis B markers in families of HbsAg-positive blood donors (in Korean). Korean J Med 1983;26:884–890.
  48. Lee JJ, Kim IM: Intrafamilial spread of hepatitis B virus infection (in Korean). Korean J Med 1982;25:1191–1198.
  49. Kong H, Kim JH, Cho NY, Kim YH, Jung KM, Yeon JE, Kim JS, Bak YT, Cho KH, Park YK, Byun KS, Lee CH: The hepatitis B carrier rate in siblings of patients with HBV-associated chronic liver disease (in Korean). Korean J Hepatol 2001;7:387–391.
  50. Lin HH, Chang MH, Chen DS, Sung JL, Hong KH, Young YC, Yang KH, Lee TY: Early predictor of the efficacy of immunoprophylaxis against perinatal hepatitis B transmission: analysis of prophylaxis failure. Vaccine1991;9:457–460.
  51. Ngui SL, Andrews NJ, Underhill GS, Heptonstall J, Teo CG: Failed postnatal immunoprophylaxis for hepatitis B: characteristics of maternal hepatitis B virus as risk factors. Clin Infect Dis 1998;27:100–106.
  52. Ip HM, Lelie PN, Wong VC, Kuhns MC, Reesink HW: Prevention of hepatitis B virus carrier state in infants according to maternal serum levels of HBV DNA. Lancet 1989;1:406–410.
  53. Lee SD, Lo KJ, Wu JC, Tsai YT, Wang JY, Ting LP, Tong MJ: Prevention of maternal-infant hepatitis B virus transmission by immunization: the role of serum hepatitis B virus DNA. Hepatology 1986;6:369–373.
  54. Korea Centers for Disease Control and Prevention: Report of the Korea Centers for Disease Control and Prevention (in Korean). 2004, pp 365–367.
  55. Song YM, Sung J, Yang S, Choe YH, Chang YS, Park WS: Factors associated with immunoprophylaxis failure against vertical transmission of hepatitis B virus. Eur J Pediatr 2007;166:813–818.
  56. Kang JH, Moon JW, Kong SH, Hwang KS, Mok JS, Lee HJ: Comparison of the seroconversion rate after primary hepatitis B vaccination and after revaccination of non-responders in full-term infants according to mother’s HBsAg seropositivity (in Korean). Korean J Pediatr 2008;51:1165–1171.
    External Resources
  57. Carman WF, Zanetti AR, Karayiannis P, Waters J, Manzillo G, Tanzi E, Zuckerman AJ, Thomas HC: Vaccine-induced escape mutant of hepatitis B virus. Lancet 1990;336:325–329.
  58. Francois G, Kew M, Van Damme P, Mphahlele M J, Meheus A: Mutant hepatitis B viruses: a matter of academic interest only or a problem with far-reaching implications? Vaccine 2001;19:3799–3815.
  59. Hsu HY, Chang MH, Ni YH, Lin HH, Wang SM, Chen DS: Surface gene mutants of hepatitis B virus in infants who develop acute or chronic infections despite immunoprophylaxis. Hepatology 1997;26:786–791.
  60. Kim JH, Koh DK, Hur JK, Kang JH, Nainan OV, Margolis HS: The incidence rate of hepatitis B virus surface gene variants in Korean children with immunoprophylaxis failure of perinatal infection (in Korean). Korean J Hepatol 2005;11:320–328.
    External Resources
  61. Lee KM, Kim YS, Ko YY, Yoo BM, Lee KJ, Kim JH, Hahm KB, Cho SW: Emergence of vaccine-induced escape mutant of hepatitis B virus with multiple surface gene mutations in a Korean child. J Korean Med Sci 2001;16:359–362.
  62. Kim B, Seo K, Park S, Kim Y, Park O, Lee HJ, Hong WK, Whang HS: Evaluation of prevention program for neonatal vertical transmission from HBsAg positive mother in Korea (in Korean). Korean J Obstet Gynecol 2005;48:2067–2072.

Article / Publication Details

First-Page Preview
Abstract of Review Article

Published online: January 05, 2010
Issue release date: January 2010

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 3

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

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