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Published: November 2009

Open Access Gateway

Primary Cutaneous Large B-Cell Lymphoma, Leg Type, Localized on the Dorsum

Patrizi A.a · Raone B.a · Sabattini E.b · Gurioli C.a · Pileri Jr. A.a · D’Acunto C.a

Author affiliations

aDermatology, Department of Internal Medicine, Geriatrics and Nephrologic Diseases, and bHemolymphopathology Unit, Institute of Hematology and Clinical Oncology ‘L.A. Seragnoli’, University of Bologna, Bologna, Italy

Corresponding Author

Prof. Annalisa Patrizi

Policlinico S. Orsola-Malpighi

Via G. Massarenti 1

IT–40138 Bologna (Italy)

Tel. +39 051 636 4847, Fax +39 051 347 847, E-Mail annalisa.patrizi@unibo.it

Related Articles for ""

Case Rep Dermatol 2009;1:87–92

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Primary cutaneous large B-cell lymphoma, leg-type (PCLBCL-LT), is a large B-cell lymphoma primarily involving the skin. It is distinguished from the other 3 subsets of this lymphoproliferative disorder by its immunohistopathological features, configuring confluent sheets of medium-sized to large B lymphocytes with round nuclei provided with evident nucleoli, resembling centroblasts or immunoblasts, which express Bcl-6, Bcl-2. Prevalently appearing on the lower limbs, as a single or multicentric and frequently ulcerated skin nodule or plaque, PCLBCL-LT has a worse prognosis than the other large B-cell lymphomas. Moreover, the age of onset is delayed (7th decade) compared to those of the other 3 subtypes (6th decade); it presents a slight female predominance (2:1), and a higher percentage of positivity to Bcl-2. We present a 52-year-old man who showed a 2-year standing, non-ulcerated, round, 4 cm in diameter, red plaque, medially located on the dorsum. After biopsy the diagnosis of PCLBCL-LT was made on histopathological and immunohistochemical studies, the latter showing positivity to CD20, Bcl-2, and Bcl-6. After treatment with radiotherapy the patient has shown a 4.4-year follow-up free of disease.

© 2009 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Published: November 2009

Published online: November 11, 2009
Issue release date: January – December

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 0

eISSN: 1662-6567 (Online)

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Open Access License / Drug Dosage / Disclaimer

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