Caries Research

Basic Science

Inhibitory Effect of Saccharin on Glycolytic Enzymes in Cell-Free Extracts of Streptococcus mutans

Linke H.A.B. · Kohn J.S.

Author affiliations

Department of Microbiology, New York University Dental Center, New York, N.Y., USA

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Caries Res 1984;18:12–16

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Article / Publication Details

First-Page Preview
Abstract of Basic Science

Published online: November 18, 2009
Issue release date: 1984

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0008-6568 (Print)
eISSN: 1421-976X (Online)

For additional information: https://www.karger.com/CRE

Abstract

Inhibitory effect of sodium saccharin in concentrations from 10––5 to 10––2M was tested on glycolytic enzymes involved in phosphate transfer in cell-free extracts of Streptococcus mutans NCTC 10449. In the presence of 10––2M sodium saccharin the enzymes hexokinase, glyceraldehyde-3-phosphate dehydrogenase, phosphoglycerate mutase, pyruvate kinase, 3-phosphoglycerate kinase and phosphofructokinase were inhibited 58, 45, ∼16, 12, 3 and 1.4%, respectively. 10––3–10––2M sodium chloride produced little if any inhibition of the glycolytic enzymes tested.

© 1984 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Basic Science

Published online: November 18, 2009
Issue release date: 1984

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0008-6568 (Print)
eISSN: 1421-976X (Online)

For additional information: https://www.karger.com/CRE


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