Caries Research

Basic Science

Isolation of Natural Plaque-Inhibiting Substances from ‘Nigerian Chewing Sticks’

Wolinsky L.E. · Sote E.O.

Author affiliations

Section of Oral Biology, School of Dentistry University of California, Los Angeles, Calif., USA

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Caries Res 1984;18:216–225

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Article / Publication Details

First-Page Preview
Abstract of Basic Science

Published online: November 18, 2009
Issue release date: 1984

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISSN: 0008-6568 (Print)
eISSN: 1421-976X (Online)

For additional information: https://www.karger.com/CRE

Abstract

Aqueous extracts, 1% (w/v), of Nigerian chewing sticks derived from the African plants Serindeia warnecki, Prosopsis africana, Pseudocedrela kotschyi, and Anoigeissus schrimperi were found to effectively inhibit the attachment of S. mutans 6715wt13 to glass or saliva-coated hydroxy-apatite beads. It was shown that the active compounds in these extracts interfere with binding of the bacteria, resulting in reduced adherence. Although no large effect upon the total extracellular glucan synthesis was noted, there was a 15% reduction in the water-insoluble polysaccharide synthesis. Chemical and spectral analysis of the active constituent from S. warnecki showed this material to have the characteristics of a high molecular weight polyphenolic tannin. 1% aqueous solution of tannic acid was also shown to promote similar in vitro adherence inhibition as the tannin-like substance from S. warnecki. In conclusion, the results imply that chewing stick constituents appear to play an important role in restricting plaque accumulation and caries incidence.

© 1984 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Basic Science

Published online: November 18, 2009
Issue release date: 1984

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISSN: 0008-6568 (Print)
eISSN: 1421-976X (Online)

For additional information: https://www.karger.com/CRE


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