Complementary Medicine Research
Letter to the Editors · Brief an die Herausgeber
Acupuncture Reduces Immune-Mediated Pulmonary Inflammatory Lesions Induced in RatsKatsuya E.M.a · Pedreira de Castro M.A.b · Whitaker Carneiro C.R.b · Yamamura Y.c · Silveira V.L.F.aa Department of Physiology, b Department of Microbiology, Immunology and Parasitology, c Department of Orthopedics and Traumatology, Federal University of São Paulo (UNIFESP), Brazil
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Article / Publication Details
Published online: December 16, 2009
Issue release date: December 2009
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 2504-2092 (Print)
eISSN: 2504-2106 (Online)
For additional information: https://www.karger.com/CMR
Abstract
Introduction: The aim of this report was to experimen-tally demonstrate the biological actions of acupuncture in an animal model of immune-mediated inflammation associated with a deposition of collagen. Materials and Methods: Male Wistar rats were sensitized by a subcu-taneous implant of heat-solidified hen egg-white and divided into 4 groups: acupuncture, sham acupuncture, immobilized, and control. Acupuncture was initiated the day after sensitization and repeated twice a week for 3 weeks. The dorsal acupoints chosen were GV-14 and BL-13, the ventral acupuncture points were LU-1, CV-17, ST-36 and SP-6. The dorsal points were stimulated manually and the ventral ones by electroacupuncture. On day 14, animals were challenged through the tail vein with Sepharose®beads coupled with ovalbumin. One week later, animals were bled, plasma corticoster-one concentrations were measured and the lungs were removed for histological evaluation. Results: Measurement of the areas of pulmonary lesion on hematoxylin-eosin stained slides showed a significant decrease (p < 0.05) in the inflammatory infiltrate in the acupuncture group, compared to the other 3 groups. Utilization of Litt and Picrosirius staining methods, in order to better visualize the infiltrate of eosinophils and the deposition of collagen, respectively, showed that both were much less intense in the acupuncture group. Corticosterone plasma levels were similar in all groups. Conclusion: Point-specific acupuncture treatment effectively reduced the inflammatory process and the deposition of collagen around ovalbumin-Sepharose beads intravenously embolized to the lungs of rats previously sensitized with the same protein that was administered subcutaneously.
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Article / Publication Details
Published online: December 16, 2009
Issue release date: December 2009
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 2504-2092 (Print)
eISSN: 2504-2106 (Online)
For additional information: https://www.karger.com/CMR
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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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