Neuroimmunomodulation

Original Paper

Time-Dependent Effect of Cyclosporine on Mitogenic Responses and Lymphocyte Subset Populations in Rat Spleen and Submaxillary Lymph Nodes

Esquifino A.I. · Arce A. · Selgas L. · Cardinali D.P.

Author affiliations

Departamento de Bioquímica y Biología Molecular III, Facultad de Medicina, Universidad Complutense, Madrid, España, y Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Argentina

Keywords: CyclosporineSpleenSubmaxillary lymph nodesImmunomodulationLymphocyte proliferationLymphocyte subsets

Related Articles for ""
Neuroimmunomodulation 2000;7:84–88
https://doi.org/10.1159/000026424

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: February 18, 2000
Issue release date: February 1999

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 0

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: https://www.karger.com/NIM

Abstract

Lipopolysaccharide (LPS)- and concanavalin A (ConA)-induced proliferation and T lymphocyte subsets were measured in spleen and submaxillary lymph nodes of male rats injected with cyclosporine (5 mg/kg s.c. for 5 days, at 12.00 or 24.00 h; animals kept under light from 08.00 to 20.00 h daily). One hour before the third injection, Freund’s complete adjuvant or its vehicle was administered. A suppressive effect of cyclosporine on the mitogenic action of LPS was seen in the spleen of rats injected with cyclosporine at noon whereas the effect of ConA remained unaffected. CD4+, CD8+ and CD4+-CD8+ cells decreased in spleen and lymph nodes of Freund’s adjuvant-injected rats only with cyclosporine given at noon. The results further support occurrence of time-of-day-dependent effects of cyclosporine on lymphocyte subsets and proliferation.

© 2000 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: February 18, 2000
Issue release date: February 1999

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 0

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: https://www.karger.com/NIM

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2000, Vol.7, No. 2

February 1999

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