Neuroimmunomodulation
Original Paper
Activation of the Hypothalamic- Pituitary-Adrenal Axis in IL-1β-Converting Enzyme-Deficient MiceLiège S.a · Moze E.a · Kelley K.W.b · Parnet P.a · Neveu P.J.aaINSERM U.394 Neurobiologie Intégrative, Institut François-Magendie, Bordeaux, France; bLaboratory of Immunophysiology, University of Illinois, Urbana, Ill., USA
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Article / Publication Details
Published online: May 04, 2000
Issue release date: May 2000
Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 0
ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)
For additional information: https://www.karger.com/NIM
Abstract
Interleukin-1β (IL-1β) plays a key role in immune, behavioral and neuroendocrine responses to inflammation or infection. IL-1β could also be involved in the response of the hypothalamic-pituitary-adrenal (HPA) axis during stress. Mature IL-1β derives from a 31-kD precursor (pro-IL-1β) that is processed by IL-1β-converting enzyme (ICE). Mice in which the ICE gene has been nullated by homologous recombination were used to investigate the role of IL-1β in the HPA axis response. Plasma levels of corticosterone and adrenocorticotropic hormone (ACTH) in response to an intraperitoneal injection of 5 μg lipopolysaccharide (LPS) were similar in ICE-deficient mice and wild-type (WT) controls. In contrast, plasma ACTH response to restraint or to 200 ng of rat recombinant IL-1β (rrIL-1β) was higher in ICE-deficient mice as compared to WT animals. This hyperreactivity of the HPA axis in ICE knockout mice appears not to be related to the production of plasma IL-1β or IL-6, which was similar to that of WT mice after rrIL-1β injection. After lypopolysaccharide, ICE-deficient mice exhibited a smaller increase in plasma-immunoreactive IL-1β and IL-6 as compared to WT controls. After restraint stress neither increase in plasma IL-1β nor IL-6 was observed. The mechanisms responsible for the increased reactivity of the HPA axis in ICE-deficient mice may result from a higher sensitivity of the HPA axis to inflammatory cytokines or to cleavage products of pro-IL-1β processed by non-ICE proteases.
© 2000 S. Karger AG, Basel
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Article / Publication Details
Published online: May 04, 2000
Issue release date: May 2000
Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 0
ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)
For additional information: https://www.karger.com/NIM
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