Login to MyKarger

New to MyKarger? Click here to sign up.



Login with Facebook

Forgot your password?

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login
(Shibboleth or Open Athens)

For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.

Biological Psychiatry
Original Paper

Decreased Blood Levels of Tumor Necrosis Factor-Alpha in Patients with Obsessive-Compulsive Disorder

Monteleone P. · Catapano F. · Fabrazzo M. · Tortorella A. · Maj M.

Author affiliations

Institute of Psychiatry, School of Medicine, University of Naples SUN, Naples, Italy

Related Articles for ""

Neuropsychobiology 1998;37:182–185

Do you have an account?

Login Information





Contact Information










I have read the Karger Terms and Conditions and agree.



Login Information





Contact Information










I have read the Karger Terms and Conditions and agree.



To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!

If you would like to redeem your KAB credit, please log in.


Save over 20% compared to the individual article price.
Learn more

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00


Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select

* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry<br>Original Paper

Published online: June 08, 1998
Issue release date: June 1998

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS

Abstract

To investigate immune system function in obsessive-compulsive disorder (OCD) we measured plasma levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6) in 14 drug-free obsessive-compulsive patients and 14 matched healthy controls. No significant differences were observed between patients and controls in plasma levels of IL-1β and IL-6, whereas plasma levels of TNF-α were significantly lower (p = 0.001) in the former. Blood levels of prolactin did not differ between the two groups, whereas plasma cortisol concentrations were significantly higher in patients than in healthy subjects (p = 0.02). No significant correlation was found between immune parameters, on the one hand, and endocrine or psychopathological measures on the other. These results suggest that OCD is associated with a decreased production in TNF-α, but normal synthesis of IL-1β and IL-6.


References

  1. Herbert TB, Cohen S: Depression and immunity: A meta-analytic overview. Psychol Bull 1993;113:472–486.
  2. Monteleone P, Fabrazzo M, Tortorella A, Maj M: Plasma levels of interleukin-6 and tumor necrosis factor alpha in chronic schizophrenia: Effects of clozapine treatment. Psychiatry Res 1997;71:11–17.
  3. Karno M, Golding JM, Sorenson SB, Burnam A: The epidemiology of obsessive-compulsive disorder in five US communities. Arch Gen Psychiatry 1988;45:1094–1099.
  4. Catapano F, Monteleone P, Maj M, Kemali D: Dexamethasone suppression test in patients with primary obsessive-compulsive disorder and in healthy controls. Neuropsychobiology 1990;23:53–56.
  5. Insel TR, Gillin JC, Moore A, Lowenstein R, Murphy DL, Mendelson W: Sleep in obsessive-compulsive disorder. Arch Gen Psychiatry 1982;39:1372–1377.
    External Resources
  6. Khanna S, Gokul BN, Reddy PL, Khanna N, Channabasavanna SM: Humoral immune function in obsessive-compulsive disorder. Indian J Psychol Med 1990;13:31–37.
  7. Khanna S, Ravi V, Shenoy PK, Chandramuki A, Channabasavanna SM: Cerebrospinal fluid viral antibodies in obsessive-compulsive disorder in an Indian population. Biol Psychiatry 1997;41:883–890.
  8. Roy BF, Benkelfat C, Hill JL, Pierce PF, Dauphin MM, Kelly TM, Sunderland T, Weinberger DR, Breslin N: Serum antibody for somatostatin-14 and prodynorphin 209-240 in patients with obsessive-compulsive disorder, schizophrenia, Alzheimer’s disease, multiple sclerosis, and advanced HIV infection. Biol Psychiatry 1994;35:335–344.
  9. Barber Y, Toren P, Achiron A, Noy S, Wolmer L, Weizman R, Laor N: T cell subsets in obsessive-compulsive disorder. Neuropsychobiology 1996;34:63–66.
    External Resources
  10. Maes M, Meltzer HY, Bosmans E: Psychoimmune investigation in obsessive-compulsive disorder: Assays of plasma transferrin, IL-2 and IL-6 receptor, and IL-1 beta and IL-6 concentrations. Neuropsychobiology 1994;30:57–60.
    External Resources
  11. Weizman R, Laor N, Barber Y, Hermesh H, Notti I, Djaldetti M, Bessler H: Cytokine production in obsessive-compulsive disorder. Biol Psychiatry 1996;40:908–912.
  12. Basedowsky HO, Del Rey A: Immune-neuro-endocrine interactions: Facts and hypotheses. Endocr Rev 1996;17:64–102.
  13. Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL, Heninger GR, Charney DS: The Yale-Brown Obsessive Compulsive Scale (YBOCS): I. Development, use and reliability. Arch Gen Psychiatry 1989;46:1006–1011.
  14. Hamilton M: A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23:56–62.
  15. Cottreaux JA, Bouvard M, Claustrat B, Juenet C: Abnormal dexamethasone suppression test in primary obsessive-compulsive patients: A confirmatory report. Psychiatry Res 1984;13:157–165.
  16. Monteleone P, Catapano F, Del Buono G, Maj M: Circadian rhythms of melatonin, cortisol and prolactin in patients with obsessive-compulsive disorder. Acta Psychiatr Scand 1994;89:411–415.
  17. O’Leary A: Stress, emotion, and human immune function. Psychol Bull 1990;108:363–392.
  18. Zuckerman SH, Shellas J, Butler LD: Differential regulation of lipopolysaccharide-induced interleukin-1 and tumor necrosis factor synthesis: Effects of endogenous and exogenous glucocorticoids and the role of pituitary-adrenal axis. Eur J Immunol 1989;19:301–305.
  19. La Via MF, Munno I, Lydiard RB, Workman EW, Hubbard JR, Michel Y, Paulling E: The influence of stress intrusion on immunodepression in generalized anxiety disorder patients and controls. Psychosom Med 1996;58:138–142.
  20. Lieberman AP, Pitha PM, Shin HS, Shin ML: Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or neurotropic viruses. Proc Natl Acad Sci USA 1989;399:608–612.
  21. Kinouchi K, Brown G, Pasternak G, Donner DB: Identification and characterisation of receptors for tumor necrosis factor-alpha in the brain. Biochem Biophys Res Commun 1991;181:1532–1538.
    External Resources
  22. Krueger JM, Takahashi S, Kapas L, Bredow S, Roky R, Fang J, Floyd R, Renegar KB, Guha-Thakurta N, Novitsky S, Obal F: Cytokines in sleep regulation. Adv Neuroimmunol 1995;5:171–188.

Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry<br>Original Paper

Published online: June 08, 1998
Issue release date: June 1998

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.