Ophthalmic Research

Original Paper

Scanning Electron Microscopy of X-Ray-Induced Cataract in Mice on Normal and Galactose Diet

Kodama T.a · Reddy V.N.a · Giblin F.a · Kinoshita J.H.b · Harding C.c

Author affiliations

aInstitute of Biological Sciences, Oakland University, Rochester, Mich. USA; bNational Eye Institute, National Institutes of Health, Bethesda, Md., USA; cKresge Eye Institute, Wayne State University, Detroit, Mich., USA

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Ophthalmic Res 1983;15:324–333

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 03, 1983
Accepted: September 15, 1983
Published online: December 04, 2009
Issue release date: 1983

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISSN: 0030-3747 (Print)
eISSN: 1423-0259 (Online)

For additional information: https://www.karger.com/ORE

Abstract

The possible multiple effect of galactose diet and X-irradiation on cataract development in mice was investigated by scanning electron microscopy. X-ray cataracts were induced by maintaining animals either on a normal or 50% galactose diet. No detectable changes in lens morphology were seen in animals fed galactose alone compared with normal controls. 2 months after X-ray, less damage had occurred to the lenses of the galactose-fed animals compared to those on a normal diet. At 4 months after X-ray, animals on a normal diet developed mature cataracts, while in the galactose-fed animals they were delayed by 0.5–1.5 months. Suppression of the development of X-ray cataract by galactose feeding may be related to the ability of this sugar, which accumulates in mouse lens due to the low levels of aldose reductase, to act as a free radical scavenger.

© 1983 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 03, 1983
Accepted: September 15, 1983
Published online: December 04, 2009
Issue release date: 1983

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISSN: 0030-3747 (Print)
eISSN: 1423-0259 (Online)

For additional information: https://www.karger.com/ORE


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