Ophthalmic Research
Original Paper
Effect of Pilocarpine on Intraocular Pressure in Ocular Hypertensive SubjectsNaveh-Floman N. · Stahl V. · Korczyn A.D.The Maurice and Gabriela Goldschleger Eye Research Institute and the Department of Physiology and Pharmacology, Tel Aviv University, Sackler School of Medicine, Ramat Aviv, Israel
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Article / Publication Details
Received: April 05, 1984
Accepted: May 20, 1985
Published online: December 04, 2009
Issue release date: 1986
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0030-3747 (Print)
eISSN: 1423-0259 (Online)
For additional information: https://www.karger.com/ORE
Abstract
In normal subjects, ocular administration of pilocarpine results in initial elevation of IOP succeeded by a fall. We have now examined the effect of pilocarpine on IOP in nontreated ocular hypertension. Our results demonstrate that the initial hypertensive phase is absent in these patients and that the subsequent hypotensive phase is more marked than in normotensive eyes. It is suggested that in normal eyes IOP is regulated by two opposing cholinergic effects, and imbalance between the two may lead to ocular hypertension (or hypotension).
© 1986 S. Karger AG, Basel
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Article / Publication Details
Received: April 05, 1984
Accepted: May 20, 1985
Published online: December 04, 2009
Issue release date: 1986
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0030-3747 (Print)
eISSN: 1423-0259 (Online)
For additional information: https://www.karger.com/ORE
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