Ophthalmic Research
Original Paper
Previous Ocular Compression Increases Intraocular Penetration of Systemic DrugsMurube J.a · Castillo T.R.c · Coronado A.b · Cabrera F.baUniversity of Alcalá-Madrid and bHospital Ramon y Cajal, Madrid, Spain; cUniversity of the Philippines, Manila, The Philippines
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Article / Publication Details
Received: November 02, 1993
Accepted: January 13, 1994
Published online: December 11, 2009
Issue release date: 1994
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 0030-3747 (Print)
eISSN: 1423-0259 (Online)
For additional information: https://www.karger.com/ORE
Abstract
Intraocular drug penetration is dependent upon the physical and chemical characteristics of the drug, the manner of drug administration and the drug’s ability to pass through the blood/aqueous barrier. Most systemically administered drugs do not achieve intraocular therapeutic levels. The authors present a new method to increase the intraocular concentration of intravenously administered drugs based on the premise that ocular hypotony by ocular compression produces a temporary break in the blood/aqueous barrier during the period of hypersecretion that follows to regain normal intraocular pressure levels. Vancomycin introduced parenterally was used as the drug model. The right eye of 22 rabbits served as experimental eye, while the left eye served as control. The concentrations of vancomycin in the aqueous humor half an hour after intravenous injection of 40 mg/kg vancomycin in 50 ml of lactated Ringer’s solution were as follows: 30.17 ± 20.68 μg/ml in the right (hypotonized) eyes and 4.92 ± 3.33 μg/ml in the left (control) eyes. The difference in drug levels between the two sets of eyes had a high statistical significance at p = 0.001.
© 1994 S. Karger AG, Basel
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Article / Publication Details
Received: November 02, 1993
Accepted: January 13, 1994
Published online: December 11, 2009
Issue release date: 1994
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 0030-3747 (Print)
eISSN: 1423-0259 (Online)
For additional information: https://www.karger.com/ORE
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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