Hormone Research in Paediatrics
Original Paper
Treatment with Thyroxine Reduces Thyroid Volume in Euthyroid Children and Adolescents with Chronic Autoimmune ThyroiditisScarpa V. · Kousta E. · Tertipi A. · Vakaki M. · Fotinou A. · Petrou V. · Hadjiathanasiou C. · Papathanasiou A.Department of Pediatric Endocrinology, ‘P. & A. Kyriakou’ Children’s Hospital, Athens, Greece
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Article / Publication Details
Received: December 01, 2008
Accepted: April 10, 2009
Published online: January 15, 2010
Issue release date: January 2010
Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 5
ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)
For additional information: https://www.karger.com/HRP
Abstract
Background/Aims: Treatment with thyroxine in children with chronic autoimmune thyroiditis (AT) is controversial. The aim of this study is to investigate, by using thyroid ultrasonography, whether thyroxine influences thyroid volume in non-goitrous euthyroid children with AT. Methods: We studied 50 euthyroid non-goitrous children and adolescents with AT for 2 years by thyroid function tests and ultrasonography; 25 were randomized to receive thyroxine and 25 did not receive treatment. Median (IQR) age was 12.1 (11.1–13.2) years. Results: At baseline there was no difference in thyroid volume SDS between the two groups (treatment group 1.1 (0.7–1.5) and controls 0.9 (0.4–1.4), respectively). After 2 years the treatment group had lower thyroid volume SDS compared to the controls (0.6 (0.3–1.0) vs. 2.0 (1.1–2.3), p = 0.001). One child of the treatment group and 12 of the control group developed goiter. Two control children developed subclinical hypothyroidism. Within the treatment group, thyroid volume SDS was lower after 2 years of treatment (p = 0.002). Within the control group, thyroid volume SDS and TSH levels increased after 2 years of follow-up (p = 0.016, 1.9 (1.5–2.8) vs. 3.2 (2.4–4.4) mIU/ml, p = 0.006, respectively). Conclusions: Treatment with thyroxine reduces thyroid volume in non-goitrous euthyroid children with AT and may prevent goiter development.
© 2010 S. Karger AG, Basel
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Article / Publication Details
Received: December 01, 2008
Accepted: April 10, 2009
Published online: January 15, 2010
Issue release date: January 2010
Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 5
ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)
For additional information: https://www.karger.com/HRP
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