Ophthalmologica
Case Report · Description de cas · Fallbericht
Progression of Choroidal Atrophy in Acute Posterior Multifocal Placoid Pigment EpitheliopathyDaniele S. · Daniele C. · Orcidi F. · Tavano A.Department of Medico-Surgical Specialities, Chair of Ophthalmology, University of Perugia, School of Medicine, Perugia, Italy
|
|
Log in to MyKarger to check if you already have access to this content.
KAB
Buy a Karger Article Bundle (KAB) and profit from a discount!
If you would like to redeem your KAB credit, please log in.
Save over 20% compared to the individual article price.
Article / Publication Details
Published online: December 04, 1997
Issue release date: January – February
Number of Print Pages: 7
Number of Figures: 7
Number of Tables: 0
ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)
For additional information: https://www.karger.com/OPH
Abstract
Acute posterior multifocal placoid pigment epitheliopathy is a non-granulomatous chorioretinitis of uncertain origin that occurs in healthy young adults. The prevailing opinion is that the disease has a good long-term prognosis for visual acuity because it is self-limiting and chorioretinal scars do not enlarge with time. A middle-aged adult male who had acute posterior multifocal placoid pigment epitheliopathy in one eye has been followed for 22 years. After apparent clinical healing of the placoid epithelial lesions, widespread severe choroidal atrophy with visual loss occurred and progressed over years without interruption. To our knowledge this is the second report of progressive deterioration of a supposedly self-limiting chorioretinal disease.
Related Articles:
References
- Gass JDM: Acute posterior multifocal placoid pigment epitheliopathy. Arch Ophthalmol 1968;80:177–185.
-
Gass JDM: Acute posterior multifocal placoid pigment epitheliopathy: A long-term follow-up study; in Fine SL, Owens SL (eds): Management of Retinal Vascular and Macular Disorders. Baltimore, Williams & Wilkins, 1983.
- Hayreh S: Optic disc vasculitis. Br J Ophthalmol 1972;56:652–670.
- Jacklin HN: Acute posterior multifocal placoid pigment epitheliopathy and thyroiditis. Arch Ophthalmol 1977;95:995–997.
- Van Busirk EM, Lessell S, Friedman E: Pigmentary epitheliopathy and erythema nodosum. Arch Ophthalmol 1971;85:369–372.
- Bridges WJ, Saadech C, Gerald R: Acute multifocal placoid pigment epitheliopathy in a patient with systemic-onset juvenile rheumatoid arthritis: Treatment with cyclosporin A and prednisone. Arthritis Rheum 1995;38:446–447.
- Dick DJ, Newman PK, Richardson J, Wilkinson R, Morley AR: Acute posterior multifocal placoid pigment epitheliopathy and sarcoidosis. Br J Ophthalmol 1988;72:74–77.
- Wolf MD, Folk JC, Panken CA, Goeken NE: HLA-B and HLA-DR″ antigens and acute posterior multifocal placoid epitheliopathy. Arch Ophthalmol 1990;108:698–700.
-
Rose S, Lou PL: Epiteliopatia acuta a placche multifocale posteriore; in Albert DM, Jakobiec FA (eds): Principi e pratica di Oftalmologia. Roma, Verduci, 1995, vol 3, pp 976–981.
- Wright BE, Bird AC, Hamilton AM: Placoid pigment epitheliopathy and Harada’s disease. Br J Ophthalmol 1978;62:609–921.
- Young NJA, Bird AC, Sehmi K: Pigment epithelial disease with abnormal choroidal perfusion. Am J Ophthalmol 1980;90:607–618.
- Gaudric A, Coscas G, Bird AC: Choroidal ischemia. Am J Ophthalmol 1982;94:489–498.
- Azar P, Gohd RS, Waltman D, Gitter KA: Acute posterior multifocal placoid pigment epitheliopathy associated with an adenovirus type 5 infection. Am J Ophthalmol 1975;80:1003–1005.
-
Brown M, Ebert A, Ladas G: Pigment epitheliopathy in a patient with a mycobacterial infection. J Pediatr Ophthalmol 1973;10:278–281.
-
Chan CC, Hooks JJ, Nussenblatt RB, Detrick B: Expression of Ia antigen on retinal pigment epithelium in experimental autoimmune uveitis. Curr Eye Res 1988;5:325–330.
- Nussenblatt RB, Palestine AG, Chan CC: Cyclosporin A therapy in the treatment of intraocular inflammatory disease resistant to systemic corticosteroids and cytotoxic agent. Am J Ophthalmol 1983;96:275–283.
-
Damato BE, Nanjiani M, Foulds WS: Acute posterior multifocal placoid pigment epitheliopathy: A follow-up study. Trans Ophthalmol Soc UK 1983;103:517–521.
-
Wolf MD, Wallace LM, Folk JC: Long-term visual function in acute posterior multifocal placoid pigment epitheliopathy. Arch Ophthalmol 1991;1109:800–803.
- Williams FD, Mieler WF: Long-term follow-up of acute multifocal posterior placoid pigment epitheliopathy. Br J Ophthalmol 1989;73:985–990.
- Deutman A, Oosterhuis J, Boen-Tan T, Aan De Kerk AL: Acute posterior multifocal placoid pigment epitheliopathy: Pigment epitheliopathy or choriocapillaritis? Br J Ophthalmol 1972;56:863–874.
- Deutman AF, Lion F: Choriocapillaris non perfusion in acute posterior multifocal placoid pigment epitheliopathy. Am J Ophthalmol 1977;84:652–657.
- Young NJA, Bird AC, Sehmi K: Pigment epithelial diseases with abnormal choroidal perfusion. Am J Ophthalmol 1980;90:607–618.
- Del Priore LV, Kaplan HJ: Pathogenesis of AMD (letter). Ophthalmology 1995;102:1125.
- Korte GE, Reppucci V, Henkind P: RPE destruction causes choriocapillary atrophy. Invest Ophthalmol Vis Sci 1984;25:1135–1145.
- Del Priore LV, Hornbeck R, Kaplan HJ, Jones Z, Valentino TL, Mosinger-Ogilvie J, Swinn M: Debridement of the pigmented retinal pigment epithelium in vivo. Arch Ophthalmol 1995;113:939–944.
Article / Publication Details
Published online: December 04, 1997
Issue release date: January – February
Number of Print Pages: 7
Number of Figures: 7
Number of Tables: 0
ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)
For additional information: https://www.karger.com/OPH
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Get Permission