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Original Paper

Platelet Monoamine Oxidase B Activity Did Not Predict Destructive Personality Traits or Violent Recidivism: A Prospective Study in Male Forensic Psychiatric Examinees

Gustavson C.a · Wass C.b · Mansson J.-E.c · Blennow K.c · Forsman A.b · Anckarsater H.a, b · Nilsson T.b

Author affiliations

aForensic Psychiatry, Malmö University Hospital, Lund University, Lund, bForensic Psychiatry, and cNeurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden

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Neuropsychobiology 2010;61:87–96

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: November 10, 2008
Accepted: July 08, 2009
Published online: January 16, 2010
Issue release date: February 2010

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 2

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS

Abstract

Aims: This prospective study was designed to replicate previous findings of an association between the platelet monoamine oxidase B (MAO-B) activity and factors of relevance for criminal behaviour in a well-documented clinical study population. Methods: Subjects (n = 77, aged 17–76 years, median 30 years) were recruited among consecutive perpetrators of severe interpersonal violent and/or sexual crimes referred to forensic psychiatric investigation. Participants were extensively investigated by structured psychiatric, psychological and social workups, including state-of-the-art rating instruments and official records, and with laboratory tests including venous blood sampling for determination of MAO-B activity. A subset of 36 individuals had lumbar punctures to measure cerebrospinal fluid concentrations of monoamine neurotransmitter metabolites. Results: Platelet MAO-B activity did not show any significant correlation with assessments of childhood behavioural disorders, substance abuse, or psychosocial adversity, nor with any crime-related factors, such as scores on the Life History of Aggression Scale, the Psychopathy Checklist or recidivistic violent crime. No significant correlation was found between MAO-B and any of the monoamine metabolites. Analyses in subgroups of smokers/non-smokers did not change this overall result. Conclusions: The findings of the present study did not support the use of MAO-B as a biological marker for aggression-related personality traits or as a predictor for violent recidivism among violent offenders.

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: November 10, 2008
Accepted: July 08, 2009
Published online: January 16, 2010
Issue release date: February 2010

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 2

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS


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