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Original Paper

Executive Dysfunction and Learning Effect after Continuous Positive Airway Pressure Treatment in Patients with Obstructive Sleep Apnea Syndrome

Saunamäki T.a, c · Himanen S.-L.d, f · Polo O.b, e · Jehkonen M.a, c

Author affiliations

Departments of aNeurology and Rehabilitation and bPulmonary Medicine, Tampere University Hospital, Departments of cPsychology, dPhysiology, and eRespiratory Diseases, University of Tampere, and fDepartment of Clinical Neurophysiology, Medical Imaging Centre, Pirkanmaa Hospital District, Tampere, Finland

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Eur Neurol 2010;63:215–220

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 29, 2009
Accepted: January 11, 2010
Published online: March 09, 2010
Issue release date: April 2010

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 2

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: https://www.karger.com/ENE

Abstract

Aims: To assess the impact of continuous positive airway pressure (CPAP) treatment on executive dysfunction in patients with obstructive sleep apnea syndrome (OSAS). Methods: At baseline, 20 OSAS patients and 17 healthy controls underwent polysomnography and neuropsychological assessment focusing on executive functions. After at least 6 months of CPAP treatment, the patients returned for one more full-night polysomnography and neuropsychological control assessment, while the controls underwent a neuropsychological control assessment. Results: All patients and controls were working-age males. OSAS severity ranged from mild to severe. Before CPAP, patients showed poorer performance than controls in the copy of the Rey-Osterrieth Complex Figure Test, the Block Design, the Digit Symbol, the Trails B and the Intra-Extra Dimensional Set-Shifting task. Patients’ executive performance showed no improvement after CPAP, and it remained poorer than the performance of controls. In addition, patients showed no learning effect in the executive tests, whereas the controls did. Conclusion: Even long-term CPAP treatment does not seem to improve OSAS patients’ mental set-shifting performance or their visuospatial organizational skills. In addition, OSAS patients have impaired learning effect in executive tests.

© 2010 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 29, 2009
Accepted: January 11, 2010
Published online: March 09, 2010
Issue release date: April 2010

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 2

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: https://www.karger.com/ENE


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