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Original Paper

Multiple Sclerosis and the Accumulation of Iron in the Basal Ganglia: Quantitative Assessment of Brain Iron Using MRI T2 Relaxometry

Burgetova A.a · Seidl Z.a, c · Krasensky J.a · Horakova D.b · Vaneckova M.a

Author affiliations

Departmentsof aRadiology and bNeurology, First Faculty of Medicine, General Teaching Hospital, Charles University in Prague, and cMedical College, Prague, Czech Republic

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Eur Neurol 2010;63:136–143

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: October 27, 2009
Accepted: November 22, 2009
Published online: January 30, 2010
Issue release date: March 2010

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 3

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: https://www.karger.com/ENE

Abstract

The aim of this work was to quantify the accumulation of iron in the basal ganglia in multiple sclerosis (MS) patients and in a control group, and to investigate the relationship between iron accumulation and other parameters assessed in MS, i.e. lesion load (LL) and brain parenchymal fraction (BPF). Magnetic resonance imaging T2 relaxometry was used for the measurement. 970 patients with clinically definite MS and 117 controls were examined. Patients were divided into three subgroups according to LL and BPF. This work provides quantitative evidence of increased iron accumulation in the basal ganglia in MS patients in comparison to healthy controls. We also found that in the subgroup with small LL value, iron accumulation is higher than in the subgroup with large LL value. The hypothesis of a neurodegenerative component of MS is supported by the changes in iron content in the brain.

© 2010 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: October 27, 2009
Accepted: November 22, 2009
Published online: January 30, 2010
Issue release date: March 2010

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 3

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: https://www.karger.com/ENE


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